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Bicuculline Ameliorated Chronic, but not Acute, Stress-Induced Feeding Suppression

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dc.contributor.authorLee, JY-
dc.contributor.authorKim, JY-
dc.contributor.authorRyu, V-
dc.contributor.authorKim, BT-
dc.contributor.authorKoo, JH-
dc.contributor.authorLee, JH-
dc.contributor.authorJahng, JW-
dc.date.accessioned2017-01-10T06:12:37Z-
dc.date.available2017-01-10T06:12:37Z-
dc.date.issued2015-
dc.identifier.issn1811-7775-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13396-
dc.description.abstractThis study was conducted to examine if γ-amino Butyric Acid (GABA)-ergic neurotransmission is implicated in the regulation of stress-induced feeding. Rats received GABAAreceptor antagonist bicuculline before each stress session during 10 days of daily restraint stress. The hypothalamic mRNA expressions of corticotropin-releasing hormone and neuropeptide Y were analyzed by in situ hybridization and the plasma corticosterone with radioimmunoassay. Bicuculline ameliorated the decrease in food intake by repeated restraints but not by a single restraint. Corticosterone increase responding to acute stress but not to repeated restraints was attenuated by bicuculline. Stress-induced expression of corticotropin-releasing hormone was blunted by bicuculline pre-treatm ent. Restraint stress did not affect neuropeptide Y expression, regardless of bicuculline pre-treatment. It is concluded that GABAAreceptors may mediate chronic but not acute, stress-induced suppression in food intake, possibly in relation with anorectic action of the hypothalamic corticotropin-releasing hormone and the hypothalamic neuropeptide Y may not be implicated in its regulatory mechanism.-
dc.language.isoen-
dc.titleBicuculline Ameliorated Chronic, but not Acute, Stress-Induced Feeding Suppression-
dc.typeArticle-
dc.identifier.urlhttp://scialert.net/abstract/?doi=ijp.2015.335.342-
dc.subject.keywordCorticosterone-
dc.subject.keywordFood intake-
dc.subject.keywordStress-
dc.subject.keywordγ-amino butyric acid-
dc.contributor.affiliatedAuthor김, 범택-
dc.type.localJournal Papers-
dc.citation.titleInternational journal of pharmacology : IJP-
dc.citation.volume11-
dc.citation.number4-
dc.citation.date2015-
dc.citation.startPage335-
dc.citation.endPage342-
dc.identifier.bibliographicCitationInternational journal of pharmacology : IJP, 11(4). : 335-342, 2015-
dc.identifier.eissn1812-5700-
dc.relation.journalidJ018117775-
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Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health
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