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Performance of HbA1c for the prediction of diabetes in a rural community in Korea.

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dc.contributor.authorSong, BM-
dc.contributor.authorKim, HC-
dc.contributor.authorLee, JY-
dc.contributor.authorLee, JM-
dc.contributor.authorKim, DJ-
dc.contributor.authorLee, YH-
dc.contributor.authorSuh, I-
dc.date.accessioned2017-01-31T04:59:41Z-
dc.date.available2017-01-31T04:59:41Z-
dc.date.issued2015-
dc.identifier.issn0742-3071-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13429-
dc.description.abstractAIM: To investigate the performance of HbA1c in predicting incident diabetes among Korean adults with normal fasting glucose and impaired fasting glucose levels.

METHODS: This study used data from the Korean Genome Epidemiology Study-Kangwha Study. A prospective analysis was carried out on 2079 people (820 men and 1259 women) who completed follow-up examinations up until 2013. Diabetes was defined as fasting blood glucose level ≥ 7.0 mmol/l, HbA1c level ≥ 48 mmol/mol (6.5%), or current treatment for diabetes. Areas under the receiver-operating characteristic curves were used to assess the different performances of HbA1c , glucose and insulin in predicting diabetes.

RESULTS: The median follow-up time was 3.97 years, during which 7.7% of men and 6.3% of women developed incident diabetes. The areas under the receiver-operating curves (95% CI) for diabetes prediction were 0.740 (0.692-0.787) for HbA1c , 0.716 (0.667-0.764) for glucose and 0.598 (0.549-0.648) for insulin. HbA1c showed better predictive power in people with impaired fasting glucose (area under the curve 0.753, 95% CI 0.685-0.821) than in those with normal glucose (area under the curve 0.648, 95% CI 0.577-0.719). An HbA1c threshold of 40 mmol/mol (5.8%) was found to have the highest predictive value for diabetes, with a relative risk of 6.30 (95% CI 3.49-11.35) in men and 3.52 (95% CI 2.06-6.03) in women after adjusting for age, waist circumference, triglycerides, hypertension, family history of diabetes, smoking, alcohol intake, exercise and baseline glucose level.

CONCLUSIONS: HbA1c can be used to identify people at high risk for the development of diabetes, especially in those with impaired fasting glucose levels.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers-
dc.subject.MESHBlood Glucose-
dc.subject.MESHCohort Studies-
dc.subject.MESHDiabetes Mellitus, Type 2-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHealth Surveys-
dc.subject.MESHHemoglobin A, Glycosylated-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHInsulin-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrediabetic State-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrevalence-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk-
dc.subject.MESHRural Health-
dc.subject.MESHSensitivity and Specificity-
dc.titlePerformance of HbA1c for the prediction of diabetes in a rural community in Korea.-
dc.typeArticle-
dc.identifier.pmid25962707-
dc.contributor.affiliatedAuthor김, 대중-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/dme.12794-
dc.citation.titleDiabetic medicine : a journal of the British Diabetic Association-
dc.citation.volume32-
dc.citation.number12-
dc.citation.date2015-
dc.citation.startPage1602-
dc.citation.endPage1610-
dc.identifier.bibliographicCitationDiabetic medicine : a journal of the British Diabetic Association, 32(12). : 1602-1610, 2015-
dc.identifier.eissn1464-5491-
dc.relation.journalidJ007423071-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
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