Cited 0 times in Scipus Cited Count

Paradoxical Associations of Insulin Resistance With Total and Cardiovascular Mortality in Humans.

DC Field Value Language
dc.contributor.authorKim, KS-
dc.contributor.authorLee, YM-
dc.contributor.authorLee, IK-
dc.contributor.authorKim, DJ-
dc.contributor.authorJacobs, DR Jr-
dc.contributor.authorLee, DH-
dc.date.accessioned2017-02-01T03:56:20Z-
dc.date.available2017-02-01T03:56:20Z-
dc.date.issued2015-
dc.identifier.issn1079-5006-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13437-
dc.description.abstractBACKGROUND: Insulin resistance is linked to many human chronic diseases. Paradoxically, however, impaired insulin signaling contributes to longevity in various organisms and is suggested as an adaptive mechanism against external stressors, including obesity. We formulated a novel hypothesis that insulin resistance can be beneficial in obese humans, insofar as it does not cause glucose dysmetabolism.

METHODS: N = 5,241 participants aged ≥40 with normal fasting glucose were combined across the 1988-1994 and 1999-2004 National Health and Nutrition Examination Survey datasets. Mean follow-up period was 6.6 years. Insulin resistance was measured with homeostasis model assessment (HOMA-IR). Outcomes were all causes (n = 724), cardiovascular diseases (CVD, n = 316), and cancer mortality (n = 190).

RESULTS: Supporting the hypothesis, obese persons with high HOMA-IR showed a decreased risk of total and CVD mortality compared to those with the lowest HOMA-IR. Adjusted hazard ratios were 1.0, 0.8, 0.4, and 0.4 (p(trend) = .02) for all death and 1.0, 0.6, 0.2, and 0.2 (p(trend) < .01) for CVD death. On the other hand, lean persons with high HOMA-IR showed about twice the total and CVD mortality compared to persons with the lowest HOMA-IR (p(trend) < .01, respectively).

CONCLUSIONS: Insulin resistance in obese individuals may begin as an adaptive mechanism and can be beneficial if it is not associated with glucose dysmetabolism. In contrast, insulin resistance in lean individuals associated with higher risk of total and CVD mortality. Insulin resistance may be multifaceted and conventional approaches to regard insulin resistance itself as a pathological condition may be reconsidered in this light.
-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBlood Glucose-
dc.subject.MESHBody Mass Index-
dc.subject.MESHCardiovascular Diseases-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance-
dc.subject.MESHLongevity-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasms-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHObesity-
dc.subject.MESHUnited States-
dc.titleParadoxical Associations of Insulin Resistance With Total and Cardiovascular Mortality in Humans.-
dc.typeArticle-
dc.identifier.pmid25326285-
dc.identifier.urlhttps://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glu194-
dc.contributor.affiliatedAuthor김, 대중-
dc.type.localJournal Papers-
dc.identifier.doi10.1093/gerona/glu194-
dc.citation.titleThe journals of gerontology. Series A, Biological sciences and medical sciences-
dc.citation.volume70-
dc.citation.number7-
dc.citation.date2015-
dc.citation.startPage847-
dc.citation.endPage853-
dc.identifier.bibliographicCitationThe journals of gerontology. Series A, Biological sciences and medical sciences, 70(7). : 847-853, 2015-
dc.identifier.eissn1758-535X-
dc.relation.journalidJ010795006-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse