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Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species.

Authors
Lee, MJ | Lee, SJ | Yun, SJ | Jang, JY | Kang, H | Kim, K  | Choi, IH | Park, S
Citation
International journal of nanomedicine, 11. : 55-68, 2015
Journal Title
International journal of nanomedicine
ISSN
1176-91141178-2013
Abstract
The silver nanoparticle (AgNP) is a candidate for anticancer therapy because of its effects on cell survival and signaling. Although numerous reports are available regarding their effect on cell death, the effect of AgNPs on metabolism is not well understood. In this study, we investigated the effect of AgNPs on glucose metabolism in hepatoma cell lines. Lactate release from both HepG2 and Huh7 cells was reduced with 5 nm AgNPs as early as 1 hour after treatment, when cell death did not occur. Treatment with 5 nm AgNPs decreased glucose consumption in HepG2 cells but not in Huh7 cells. Treatment with 5 nm AgNPs reduced nuclear factor erythroid 2-like 2 expression in both cell types without affecting its activation at the early time points after AgNPs' treatment. Increased reactive oxygen species (ROS) production was detected 1 hour after 5 nm AgNPs' treatment, and lactate release was restored in the presence of an ROS scavenger. Our results suggest that 5 nm AgNPs affect glucose metabolism by producing ROS.
MeSH

DOI
10.2147/IJN.S94907
PMID
26730190
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Ajou Authors
김, 경민  |  박, 선
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