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The relevance of miRNA-21 in HSV-induced inflammation in a mouse model.

Authors
Choi, B | Kim, HA  | Suh, CH  | Byun, HO  | Jung, JY  | Sohn, S
Citation
International journal of molecular sciences, 16(4). : 7413-7427, 2015
Journal Title
International journal of molecular sciences
ISSN
1422-0067
Abstract
The purpose of this study was to clarify the correlation between microRNA-21 (miR-21) expression and inflammation in a herpes simplex virus (HSV)-induced Behçet's Disease (BD) mouse model. miR-21 was compared between BD patients and healthy controls in peripheral blood mononuclear cells (PBMC). For miR-21 inhibition, miR-21 antagomir was applied to BD mice. The change of symptoms was monitored. The levels of cytokines and related molecules were determined by ELISA and real time qPCR. Treatment with colchicine or pentoxifylline down-regulated the level of miR-21 with improved symptoms in mice. miR-21 inhibition was accompanied by down-regulated serum levels of IL-17 and IL-6. The expression levels of PDCD4, RhoB, PD-1, IL-12p35, and toll-like receptor-4 were also regulated by miR-21 inhibition. miR-21 was correlated with HSV-induced BD-like inflammation in mice and BD patients. The expression of miR-21 was regulated by antagomir in mice.
MeSH

DOI
10.3390/ijms16047413
PMID
25849652
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > Research Organization > Inflamm-aging Translational Research Center
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Ajou Authors
김, 현아  |  변, 해옥  |  서, 창희  |  손, 성향  |  정, 주양
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