Cited 0 times in Scipus Cited Count

Epstein-Barr virus-positive nodal T/NK-cell lymphoma: an analysis of 15 cases with distinct clinicopathological features.

DC Field Value Language
dc.contributor.authorJeon, YK-
dc.contributor.authorKim, JH-
dc.contributor.authorSung, JY-
dc.contributor.authorHan, JH-
dc.contributor.authorKo, YH-
dc.contributor.authorHematopathology Study Group of the Korean Society of Pathologists-
dc.date.accessioned2017-03-10T05:51:41Z-
dc.date.available2017-03-10T05:51:41Z-
dc.date.issued2015-
dc.identifier.issn0046-8177-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13494-
dc.description.abstractNodal peripheral T-cell lymphoma, not otherwise specified, is a heterogeneous entity with variable biologic behavior. We analyze the clinicopathological features of 15 patients with Epstein-Barr virus-positive (EBV+) nodal T/NK-cell lymphoma, including 9 males and 6 females, with a median age of 64 years. All patients presented with multiple lymphadenopathy with common B symptoms (80%, 12/15) at an advanced Ann Arbor stage (III, IV) (87%, 13/15). The International Prognostic Index was high or high/intermediate in 87% (13/15) of patients, and the prognostic index for peripheral T-cell lymphoma was group 3 or 4 in 73% (11/15). Spleen and liver involvement was observed in 73% (11/15) and 60% (9/15) of patients, respectively. In contrast, extranodal involvement was infrequent, with no more than 1 site in 71% (10/15) of patients. Moreover, none had nasal lesions, and only 1 had mucocutaneous involvement. The cell lineage of EBV+ tumor cells was determined to be T cell in all except 1 patient, who was NK-cell lineage. Cytotoxic molecules were expressed in all cases, and 64% (9/14) of patients expressed the αβT-cell receptor. Moreover, most patients (67%, 10/15) showed CD8 positivity, with 2 of them being CD4CD8 double positive; the others were CD4 positive (n = 2) or CD4CD8 double negative (n = 3). The clinical course was very aggressive, with a median survival time of 3.5 months, and 10 patients died within 6 months of diagnosis. Taken together, our data demonstrate that EBV+ nodal T/NK-cell lymphoma is a distinct clinicopathological entity characterized by cytotoxic molecule expression, a frequent CD8-positive αβT-cell lineage, and a very aggressive clinical behavior.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers, Tumor-
dc.subject.MESHBiopsy-
dc.subject.MESHCD4-Positive T-Lymphocytes-
dc.subject.MESHCD8-Positive T-Lymphocytes-
dc.subject.MESHCell Lineage-
dc.subject.MESHEpstein-Barr Virus Infections-
dc.subject.MESHFemale-
dc.subject.MESHHerpesvirus 4, Human-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHIn Situ Hybridization-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHKiller Cells, Natural-
dc.subject.MESHLymphoma, Extranodal NK-T-Cell-
dc.subject.MESHLymphoma, T-Cell, Peripheral-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHRNA, Viral-
dc.subject.MESHReceptors, Antigen, T-Cell, alpha-beta-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleEpstein-Barr virus-positive nodal T/NK-cell lymphoma: an analysis of 15 cases with distinct clinicopathological features.-
dc.typeArticle-
dc.identifier.pmid25907865-
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0046-8177(15)00086-6-
dc.contributor.affiliatedAuthor한, 재호-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.humpath.2015.03.002-
dc.citation.titleHuman pathology-
dc.citation.volume46-
dc.citation.number7-
dc.citation.date2015-
dc.citation.startPage981-
dc.citation.endPage990-
dc.identifier.bibliographicCitationHuman pathology, 46(7). : 981-990, 2015-
dc.identifier.eissn1532-8392-
dc.relation.journalidJ000468177-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse