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Attentional distractibility by optokinetic stimulation in Alzheimer disease.

Authors
Kim, EJ; Lee, BH; Seo, SW; Moon, SY; Jung, DS; Park, KH; Heilman, KM; Na, DL
Citation
Neurology, 69(11):1105-1112, 2007
Journal Title
Neurology
ISSN
0028-38781526-632X
Abstract
OBJECTIVE: Unilateral temporoparietal injury may result in an attentional deficit for stimuli presented in contralesional space. Thus, bilateral temporoparietal degeneration associated with Alzheimer disease (AD) might result in a bilateral attentional disturbance. Tests for hemispatial neglect, however, primarily assess spatial attentional asymmetries, and a bilateral attentional disorder might not be detected with these tests. The goal of this study was to learn whether optokinetic stimulation (OKS) would perturb the balanced attentional deficits of AD patients and alter their spatial allocation of attention. METHODS: In Experiment I, 10 AD patients with bilateral temporoparietal glucose hypometabolism on PET and 10 controls bisected lines in two conditions: stationary solid lines superimposed on a moving background and "striped lines" where the whole line was stationary but the stripes within the line moved. The background OKS or the stripes within the line moved leftward or rightward or were stationary. In Experiment II, to investigate whether the influence of background movements would increase with AD severity, we conducted a similar experiment in 56 patients with various stages of AD. RESULTS: In Experiment I, the line bisection errors (LBEs) of AD subjects, but not of the controls, were markedly influenced by both background and within line stripe motions, deviations occurring in the same direction of movement. In Experiment II, LBEs also occurred in the same direction as background movement and increased with dementia severity. CONCLUSIONS: These results demonstrate that patients with Alzheimer disease are spatially distracted by moving stimuli.
MeSH terms
AgedAlzheimer Disease/metabolismAlzheimer Disease/physiopathology*Alzheimer Disease/radionuclide imagingAttention*/physiologyBrain/metabolismBrain/physiopathology*Brain/radionuclide imagingBrain MappingCognition Disorders/metabolismCognition Disorders/physiopathology*Cognition Disorders/radionuclide imagingFemaleFunctional Laterality/physiologyHumansMaleMiddle AgedMotion PerceptionNeuropsychological TestsNystagmus, Optokinetic/physiologyPerceptual Disorders/etiologyPerceptual Disorders/physiopathology*Photic Stimulation/methodsPositron-Emission TomographyPredictive Value of TestsSpace Perception/physiologyVisual Fields/physiology
DOI
10.1212/01.wnl.0000276956.65528.d4
PMID
17846410
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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