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Pretreatment serum CYFRA 21-1 level correlates significantly with survival of cervical cancer patients: a multivariate analysis of 506 cases.

DC Field Value Language
dc.contributor.authorPiao, X-
dc.contributor.authorKong, TW-
dc.contributor.authorChang, SJ-
dc.contributor.authorPaek, J-
dc.contributor.authorChun, M-
dc.contributor.authorRyu, HS-
dc.date.accessioned2017-03-15T01:05:07Z-
dc.date.available2017-03-15T01:05:07Z-
dc.date.issued2015-
dc.identifier.issn0090-8258-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13527-
dc.description.abstractOBJECTIVE: To determine whether pretreatment CYFRA 21-1 levels can be a useful prognostic indicator in cervical cancer with reference to squamous cell carcinoma-antigen (SCC-Ag).

METHODS: We retrospectively analyzed data on 506 consecutive cervical cancer patients who were treated by radical hysterectomy or primary concurrent chemoradiation therapy. The pretreatment serum SCC-Ag and serum CYFRA 21-1 levels were measured in these patients. A multivariate analysis using Cox's proportional hazard model was performed to evaluate the prognostic significance of pretreatment variables.

RESULTS: In patients who underwent radical hysterectomy, there was a significant correlation between pretreatment serum SCC-Ag/CYFRA 21-1 levels and patient age, advanced FIGO stage, large tumor size, lymph node metastasis, and deep stromal invasion. In the stepwise Cox regression analysis, large tumor size >4cm was an independent prognostic factor for disease-free survival (OR, 3.110; [95% CI, 1.588-6.093], P=0.001) and overall survival (OR, 8.497; [95% CI, 1.797-40.184], P=0.007) in patients with squamous cell carcinoma, while pretreatment CYFRA 21-1 (P=0.010) serum levels had a significant independent effect on overall survival. Likewise, pretreatment CYFRA 21-1 (P<0.001 and P=0.006) serum levels were the only independent prognostic factor for disease-free survival and overall survival in patients with non-squamous cell carcinoma.

CONCLUSION: Pretreatment CYFRA 21-1 levels may be considered as a useful prognostic indicator in cervical cancer with reference to SCC-Ag.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntigens, Neoplasm-
dc.subject.MESHBiomarkers, Tumor-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKeratin-19-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSerpins-
dc.subject.MESHUterine Cervical Neoplasms-
dc.subject.MESHYoung Adult-
dc.titlePretreatment serum CYFRA 21-1 level correlates significantly with survival of cervical cancer patients: a multivariate analysis of 506 cases.-
dc.typeArticle-
dc.identifier.pmid25913134-
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0090-8258(15)00831-8-
dc.contributor.affiliatedAuthor공, 태욱-
dc.contributor.affiliatedAuthor장, 석준-
dc.contributor.affiliatedAuthor백, 지흠-
dc.contributor.affiliatedAuthor전, 미선-
dc.contributor.affiliatedAuthor유, 희석-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.ygyno.2015.04.012-
dc.citation.titleGynecologic oncology-
dc.citation.volume138-
dc.citation.number1-
dc.citation.date2015-
dc.citation.startPage89-
dc.citation.endPage93-
dc.identifier.bibliographicCitationGynecologic oncology, 138(1). : 89-93, 2015-
dc.identifier.eissn1095-6859-
dc.relation.journalidJ000908258-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
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