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A Dunnione Compound MB12662 Improves Cisplatin-Induced Tissue Injury and Emesis.

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dc.contributor.authorPark, D-
dc.contributor.authorJo, IG-
dc.contributor.authorJang, JY-
dc.contributor.authorKwak, TH-
dc.contributor.authorYoo, SK-
dc.contributor.authorJeon, JH-
dc.contributor.authorChoi, EK-
dc.contributor.authorJoo, SS-
dc.contributor.authorKim, O-
dc.contributor.authorKim, YB-
dc.date.accessioned2017-03-16-
dc.date.available2017-03-16-
dc.date.issued2015-
dc.identifier.issn1976-9148-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13545-
dc.description.abstractThe present study was aimed to investigate the effects of MB12662, a synthetic dunnione compound, on cisplatin-induced vomiting reflexes and intestinal, renal, immune system, and hematopoietic toxicities in ferrets and mice, respectively. Male ICR mice were orally administered MB12662 (5, 10, 25 or 50 mg/kg) for 10 days, during which intraperitoneally challenged with cisplatin (3.5 mg/kg) from day 4 to 7, and sacrificed on day 10 for the pathological examination. Male ferrets were orally administered MB12662 (25, 50 or 100 mg/kg) for 7 days, subcutaneously challenged with cisplatin (5 mg/kg), and monitored for vomiting reflexes and survival of the animals. Four-day injection of cisplatin (3.5 mg/kg) to mice caused body weight loss and degeneration and atrophy of intestinal villi, reducing villi/crypt ratio to a half level of control animals. Cisplatin also induced renal and hepatic toxicities, and depletion of splenocytes and bone marrow progenitor cells. The systemic toxicities including decreased villi/crypt ratio, immune system atrophy, splenocyte depletion, and decreased cellularity in bone marrow were improved by MB12662. Cisplatin (5 mg/kg) induced retching and emetic responses of ferrets, which were remarkably attenuated by MB12662 in a dose-dependent manner. All the ferrets pretreated with MB12662 survived the challenge of cisplatin, in comparison with 40% mortality in vehicle-treated animals, and blood parameters of nephrotoxicity and hepatotoxicity were markedly recovered. It is expected that MB12662 could be a candidate for the body protection against burden, including emesis, of chemotherapeutic agents.-
dc.language.isoen-
dc.titleA Dunnione Compound MB12662 Improves Cisplatin-Induced Tissue Injury and Emesis.-
dc.typeArticle-
dc.identifier.pmid26336585-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556205/-
dc.subject.keywordCisplatin-
dc.subject.keywordDunnione-
dc.subject.keywordEmesis-
dc.subject.keywordIntestinal injury-
dc.subject.keywordMB12662-
dc.subject.keywordNephrotoxicity-
dc.contributor.affiliatedAuthor박, 동선-
dc.type.localJournal Papers-
dc.identifier.doi10.4062/biomolther.2015.034-
dc.citation.titleBiomolecules & therapeutics-
dc.citation.volume23-
dc.citation.number5-
dc.citation.date2015-
dc.citation.startPage449-
dc.citation.endPage457-
dc.identifier.bibliographicCitationBiomolecules & therapeutics, 23(5). : 449-457, 2015-
dc.identifier.eissn2005-4483-
dc.relation.journalidJ019769148-
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Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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