Cited 0 times in Scipus Cited Count

Comparative Study of Growth Hormone Treatment in Children with Idiopathic Short Stature and Growth Hormone Deficiency.

DC Field Value Language
dc.contributor.authorJeong, HR-
dc.contributor.authorKwon, EB-
dc.contributor.authorShim, YS-
dc.contributor.authorLee, HS-
dc.contributor.authorHwang, JS-
dc.date.accessioned2017-03-17T10:31:43Z-
dc.date.available2017-03-17T10:31:43Z-
dc.date.issued2015-
dc.identifier.issn1389-2002-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13578-
dc.description.abstractBACKGROUND/AIMS: Idiopathic short stature (ISS) is defined as short stature of unknown origin. Responses to growth hormone (GH) in children with ISS are highly variable and dose-dependent, and the optimal treatment is controversial. This study was performed to compare the effects of GH treatment in prepubertal children with ISS versus growth hormone deficiency (GHD).

METHODS: This retrospective study was conducted at Ajou University Hospital, Korea. Children with GHD (n = 38) or ISS (n = 22) were treated with GH (0.23 mg/kg/week, 6 times a week) for 2 years. All subjects were prepubertal during the study period. The auxological parameters and growth outcome of the two groups were compared. The association of initial clinical characteristics and first-year height standard deviation scores (Δ height SDS) was analyzed.

RESULTS: No differences were observed in the baseline auxological parameters between the ISS and GHD groups. Growth outcomes in the first and second years were similar in both groups. Age was negatively associated with first-year change in Δ height SDS in both groups.

CONCLUSIONS: GH treatment was effective in both children with ISS and those with GHD. Early intervention with GH is the most appropriate therapeutic option in both ISS and GHD.
-
dc.language.isoen-
dc.subject.MESHAge Factors-
dc.subject.MESHBody Height-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHFemale-
dc.subject.MESHHospitals, University-
dc.subject.MESHHuman Growth Hormone-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleComparative Study of Growth Hormone Treatment in Children with Idiopathic Short Stature and Growth Hormone Deficiency.-
dc.typeArticle-
dc.identifier.pmid26467072-
dc.identifier.urlhttp://www.eurekaselect.com/135817/article-
dc.contributor.affiliatedAuthor권, 은별-
dc.contributor.affiliatedAuthor이, 해상-
dc.contributor.affiliatedAuthor황, 진순-
dc.type.localJournal Papers-
dc.citation.titleCurrent drug metabolism-
dc.citation.volume16-
dc.citation.number10-
dc.citation.date2015-
dc.citation.startPage940-
dc.citation.endPage946-
dc.identifier.bibliographicCitationCurrent drug metabolism, 16(10). : 940-946, 2015-
dc.identifier.eissn1875-5453-
dc.relation.journalidJ013892002-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse