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Usefulness of casein specific IgE and IgG antibodies to immediate type cow’s milk allergy

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dc.contributor.authorLim, JH-
dc.contributor.authorJeong, KU-
dc.contributor.authorLee, JM-
dc.contributor.authorLee, KE-
dc.contributor.authorLee, S-
dc.date.accessioned2017-03-21T02:45:08Z-
dc.date.available2017-03-21T02:45:08Z-
dc.date.issued2015-
dc.identifier.issn2288-0402-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13599-
dc.description.abstractPurpose: Cow's milk-specific IgE (CM-IgE) has been proposed as one of the valuable markers for diagnosis of clinical cow's milk (CM) allergy. In this study, we evaluated the additional usefulness of casein-specific IgE (casein-IgE) and IgG (casein-IgG) for the diagnosis of clinical CM allergy.

Methods: Fifty-eight subjects, aged from 3 months to 154 months, were enrolled. Thirty-four patients showed immediate-type of clinical CM allergy, and 24 patients were atopic controls. The serum levels of CM-IgE, casein-IgE, and casein-IgG were measured. Patients were divided into 2 groups: those aged under 12 months and those aged 12 months or over. The diagnostic values of each antibody were analyzed and compared using the Mann-Whitney U-test and receiver operating characteristic curves.

Results: CM allergy had significantly higher levels of CM-IgE and casein-IgE, and lower levels of casein-IgG/IgE ratio when compared to atopic controls in both age groups (P<0.05). CM-IgE and casein-IgE were shown to be better predictive markers for immediate-type CM allergy in patients under 12 months, while casein-IgG/IgE ratio was a more useful marker in those aged 12 months or over. Considering 100% positive predictive values, cutoff points were 1.04 kU/L for CM-IgE, 0.11 kU/L for casein-IgE, 19.5 for casein-IgG/IgE ratio in patients aged under 12 months, and 7.1 kU/L for CM-IgE, 1.41 kU/L for casein-IgE, 12.51 for casein-IgG/IgE ratio in those aged 12 months or over.

Conclusion: CM-IgE, casein-IgE, and casein-IgG/IgE ratio are useful markers for predicting immediate-type CM allergy. Further studies are needed on diagnostic decision points for CM allergy using combination of cutoff values of these 3 markers.
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dc.language.isoko-
dc.titleUsefulness of casein specific IgE and IgG antibodies to immediate type cow’s milk allergy-
dc.title.alternative즉시형 우유 알레르기 환자에서 카제인 특이 IgE와 IgG의 유용성-
dc.typeArticle-
dc.subject.keywordMilk hypersensitivity-
dc.subject.keywordCaseins-
dc.subject.keywordImmunoglobulin E-
dc.subject.keywordImmunoglobulin G-
dc.subject.keywordAnaphylaxis-
dc.contributor.affiliatedAuthor정, 경욱-
dc.contributor.affiliatedAuthor이, 수영-
dc.type.localJournal Papers-
dc.identifier.doi10.4168/aard.2015.3.2.139-
dc.citation.titleAllergy asthma & respiratory disease-
dc.citation.volume3-
dc.citation.number2-
dc.citation.date2015-
dc.citation.startPage139-
dc.citation.endPage144-
dc.identifier.bibliographicCitationAllergy asthma & respiratory disease, 3(2). : 139-144, 2015-
dc.identifier.eissn2288-0410-
dc.relation.journalidJ022880402-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
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