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The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia.

Authors
Kim, SB | Lee, JH  | Lee, J | Shin, SH | Eun, HS | Lee, SM | Sohn, JA | Kim, HS | Choi, BM | Park, MS  | Park, KI | Namgung, R
Citation
Korean journal of pediatrics, 58(9). : 347-353, 2015
Journal Title
Korean journal of pediatrics
ISSN
1738-10612092-7258
Abstract
PURPOSE: The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD).

METHODS: The Interventional study was designed as a multicenter, prospective, and randomized trial, with open labeled and parallel-experimental groups, 66 infants were enrolled and allocated to either the case group (n=30) or the control group (n=36) based on gestational age (GA). Infants in the case group were given Montelukast sodium (Singulair) based on their body weight (BW). Zero week was defined as the start time of the study.

RESULTS: The incidence of moderate to severe BPD was not different between the groups (case group: 13 of 30 [43.3%] vs. control group: 19 of 36 [52.8%], P=0.912). Additionally, secondary outcomes such as ventilation index, mean airway pressure and resort to systemic steroids were not significantly different. There were no serious adverse drug reactions in either group, and furthermore the rate of occurrence of mild drug related-events were not significantly different (case group: 10 of 42 [23.8%] vs. control group: 6 of 48 (15.8%), P=0.414).

CONCLUSION: Montelukast was not effective in reducing moderate or severe BPD. There were no significant adverse drug events associated with Montelukast treatment.
Keywords
DOI
10.3345/kjp.2015.58.9.347
PMID
26512261
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Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Ajou Authors
박, 문성  |  이, 장훈
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