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High circulating microRNA-122 expression is a poor prognostic marker in patients with hepatitis B virus-related hepatocellular carcinoma who undergo radiofrequency ablation.

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dc.contributor.authorCho, HJ-
dc.contributor.authorKim, JK-
dc.contributor.authorNam, JS-
dc.contributor.authorWang, HJ-
dc.contributor.authorLee, JH-
dc.contributor.authorKim, BW-
dc.contributor.authorKim, SS-
dc.contributor.authorNoh, CK-
dc.contributor.authorShin, SJ-
dc.contributor.authorLee, KM-
dc.contributor.authorCho, SW-
dc.contributor.authorCheong, JY-
dc.date.accessioned2017-03-22T05:48:17Z-
dc.date.available2017-03-22T05:48:17Z-
dc.date.issued2015-
dc.identifier.issn0009-9120-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13616-
dc.description.abstractOBJECTIVES: Aim of this study was to investigate the prognostic potential of plasma microRNA-122 levels in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma after hepatic resection or radiofrequency ablation (RFA).

DESIGN AND METHODS: A total of 120 patients with HBV-related hepatocellular carcinoma who underwent hepatic resection (n=63) or RFA (n=57) were included. The pretreatment plasma microRNA-122 level was assessed using quantitative real time polymerase chain reaction, and the correlation between microRNA-122 expression and various clinical parameters was investigated.

RESULTS: Multivariate Cox regression analysis demonstrated that, in all patients, a low platelet count (<100×10(9)/L), low albumin level (≤3.5g/dL.), and advanced tumor stage (modified Union for International Cancer Control stage III/IV) were independent prognostic factors for disease-free survival, while a low albumin level and advanced tumor stage were independent prognostic factors for overall survival (OS). In a subgroup analysis of patients who underwent RFA, the patients with high miR-122 expression (>100) had significantly lower OS on Kaplan-Meier analysis (P=0.042). Furthermore, high microRNA-122 expression (hazard ratio [HR]=2.67; 95% confidence interval [CI]=1.12-6.35; P=0.026) and advanced tumor stage (HR=2.27; 95% CI=1.23-4.18; P=0.009) were independent risk factors for poor OS in patients treated with RFA. The combination of microRNA-122 and tumor stage resulted in an area under the curve of 0.818 for predicting 1-year OS in patients who underwent RFA.

CONCLUSIONS: High plasma microRNA-122 expression was associated with poor OS in patients with HBV-related hepatocellular carcinoma who underwent RFA.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor-
dc.subject.MESHCarcinoma, Hepatocellular-
dc.subject.MESHCatheter Ablation-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B-
dc.subject.MESHHepatitis B virus-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms-
dc.subject.MESHMale-
dc.subject.MESHMicroRNAs-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHRisk Factors-
dc.titleHigh circulating microRNA-122 expression is a poor prognostic marker in patients with hepatitis B virus-related hepatocellular carcinoma who undergo radiofrequency ablation.-
dc.typeArticle-
dc.identifier.pmid26129878-
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0009-9120(15)00257-X-
dc.contributor.affiliatedAuthor조, 효정-
dc.contributor.affiliatedAuthor김, 재근-
dc.contributor.affiliatedAuthor왕, 희정-
dc.contributor.affiliatedAuthor이, 제희-
dc.contributor.affiliatedAuthor김, 봉완-
dc.contributor.affiliatedAuthor김, 순선-
dc.contributor.affiliatedAuthor노, 충균-
dc.contributor.affiliatedAuthor신, 성재-
dc.contributor.affiliatedAuthor이, 기명-
dc.contributor.affiliatedAuthor조, 성원-
dc.contributor.affiliatedAuthor정, 재연-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.clinbiochem.2015.06.019-
dc.citation.titleClinical biochemistry-
dc.citation.volume48-
dc.citation.number16-17-
dc.citation.date2015-
dc.citation.startPage1073-
dc.citation.endPage1078-
dc.identifier.bibliographicCitationClinical biochemistry, 48(16-17). : 1073-1078, 2015-
dc.identifier.eissn1873-2933-
dc.relation.journalidJ000099120-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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