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Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci of STAT4 and HLA-DQ in a Korean population.

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dc.contributor.authorKim, LH-
dc.contributor.authorCheong, HS-
dc.contributor.authorNamgoong, S-
dc.contributor.authorKim, JO-
dc.contributor.authorKim, JH-
dc.contributor.authorPark, BL-
dc.contributor.authorCho, SW-
dc.contributor.authorPark, NH-
dc.contributor.authorCheong, JY-
dc.contributor.authorKoh, I-
dc.contributor.authorShin, HD-
dc.contributor.authorKim, YJ-
dc.date.accessioned2017-03-22T06:43:52Z-
dc.date.available2017-03-22T06:43:52Z-
dc.date.issued2015-
dc.identifier.issn1567-1348-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13621-
dc.description.abstractA recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population. We attempted to replicate the associations between the two SNP loci and the risk of HCC in a Korean population. The rs7574865 in STAT4 and rs9275319 in HLA-DQ were genotyped in a total of 3838 Korean subjects composed of 287 HBV-related hepatocellular carcinoma patients, 671 chronic hepatitis B virus (CHB) patients, and 2880 population controls using TaqMan genotyping assay. Gene expression was measured by microarray. A logistic regression analysis revealed that rs7574865 in STAT4 and rs9275319 in HLA-DQ were associated with the risk of CHB (OR = 1.25, P = 0.0002 and OR = 1.57, P= 1.44 × 10(-10), respectively). However, these loci were no association with the risk of HBV-related HCC among CHB patients. In the gene expression analyses, although no significant differences in mRNA expression of nearby genes according to genotypes were detected, a significantly decreased mRNA expression in HCC subjects was observed in STAT4, HLA-DQA1, and HLA-DQB1. Although the genetic effects of two HCC susceptibility loci were not replicated, the two loci were found to exert susceptibility effects on the risk of CHB in a Korean population. In addition, the decreased mRNA expression of STAT4, HLA-DQA1, and HLA-DQB1 in HCC tissue might provide a clue to understanding their role in the progression to HCC.-
dc.language.isoen-
dc.subject.MESHAlleles-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHCarcinoma, Hepatocellular-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenetic Loci-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHGenome-Wide Association Study-
dc.subject.MESHGenotype-
dc.subject.MESHHLA-DQ Antigens-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms-
dc.subject.MESHMale-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHSTAT4 Transcription Factor-
dc.titleReplication of genome wide association studies on hepatocellular carcinoma susceptibility loci of STAT4 and HLA-DQ in a Korean population.-
dc.typeArticle-
dc.identifier.pmid25913043-
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1567-1348(15)00138-0-
dc.contributor.affiliatedAuthor조, 성원-
dc.contributor.affiliatedAuthor정, 재연-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.meegid.2015.04.013-
dc.citation.titleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases-
dc.citation.volume33-
dc.citation.date2015-
dc.citation.startPage72-
dc.citation.endPage76-
dc.identifier.bibliographicCitationInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 33. : 72-76, 2015-
dc.identifier.eissn1567-7257-
dc.relation.journalidJ015671348-
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Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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