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Partially covered versus uncovered self-expandable nitinol stents with anti-migration properties for the palliation of malignant distal biliary obstruction: A randomized controlled trial.

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dc.contributor.authorYang, MJ-
dc.contributor.authorKim, JH-
dc.contributor.authorYoo, BM-
dc.contributor.authorHwang, JC-
dc.contributor.authorYoo, JH-
dc.contributor.authorLee, KS-
dc.contributor.authorKang, JK-
dc.contributor.authorKim, SS-
dc.contributor.authorLim, SG-
dc.contributor.authorShin, SJ-
dc.contributor.authorCheong, JY-
dc.contributor.authorLee, KM-
dc.contributor.authorLee, KJ-
dc.contributor.authorCho, SW-
dc.date.accessioned2017-03-23T10:03:36Z-
dc.date.available2017-03-23T10:03:36Z-
dc.date.issued2015-
dc.identifier.issn0036-5521-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13629-
dc.description.abstractOBJECTIVE: Covered self-expandable metal stents (SEMSs) are increasingly used as alternatives to uncovered SEMSs for the palliation of inoperable malignant distal biliary obstruction to counteract tumor ingrowth. We aimed to compare the outcomes of partially covered and uncovered SEMSs with identical mesh structures and anti-migration properties, such as low axial force and flared ends.

MATERIALS AND METHODS: One hundred and three patients who were diagnosed with inoperable malignant distal biliary obstruction between January 2006 and August 2013 were randomly assigned to either the partially covered (n = 51) or uncovered (n = 52) SEMS group.

RESULTS: There were no significant differences in the cumulative stent patency, overall patient survival, stent dysfunction-free survival and overall adverse events, including pancreatitis and cholecystitis, between the two groups. Compared to the uncovered group, stent migration (5.9% vs. 0%, p = 0.118) and tumor overgrowth (7.8% vs. 1.9%, p = 0.205) were non-significantly more frequent in the partially covered group, whereas tumor ingrowth showed a significantly higher incidence in the uncovered group (5.9% vs. 19.2%, p = 0.041). Stent migration in the partially covered group occurred only in patients with short stenosis of the utmost distal bile duct (two in ampullary cancer, one in bile duct cancer), and did not occur in any patients with pancreatic cancer.

CONCLUSIONS: For the palliation of malignant distal biliary obstruction, endoscopic placement of partially covered SEMSs with anti-migration designs and identical mesh structures to uncovered SEMSs failed to prolong cumulative stent patency or reduce stent migration.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHAlloys-
dc.subject.MESHBile Duct Neoplasms-
dc.subject.MESHCholecystitis-
dc.subject.MESHEndoscopes, Gastrointestinal-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPalliative Care-
dc.subject.MESHPancreatitis-
dc.subject.MESHPostoperative Complications-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHStents-
dc.subject.MESHTreatment Outcome-
dc.titlePartially covered versus uncovered self-expandable nitinol stents with anti-migration properties for the palliation of malignant distal biliary obstruction: A randomized controlled trial.-
dc.typeArticle-
dc.identifier.pmid26133200-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26087862/-
dc.contributor.affiliatedAuthor김, 진홍-
dc.contributor.affiliatedAuthor유, 병무-
dc.type.localJournal Papers-
dc.identifier.doi10.3109/00365521.2015.1057219-
dc.citation.titleScandinavian journal of gastroenterology-
dc.citation.volume50-
dc.citation.number12-
dc.citation.date2015-
dc.citation.startPage1490-
dc.citation.endPage1499-
dc.identifier.bibliographicCitationScandinavian journal of gastroenterology, 50(12). : 1490-1499, 2015-
dc.identifier.eissn1502-7708-
dc.relation.journalidJ000365521-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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