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Randomized Trial of Stents Versus Bypass Surgery for Left Main Coronary Artery Disease: 5-Year Outcomes of the PRECOMBAT Study.

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dc.contributor.authorAhn, JM-
dc.contributor.authorRoh, JH-
dc.contributor.authorKim, YH-
dc.contributor.authorPark, DW-
dc.contributor.authorYun, SC-
dc.contributor.authorLee, PH-
dc.contributor.authorChang, M-
dc.contributor.authorPark, HW-
dc.contributor.authorLee, SW-
dc.contributor.authorLee, CW-
dc.contributor.authorPark, SW-
dc.contributor.authorChoo, SJ-
dc.contributor.authorChung, C-
dc.contributor.authorLee, J-
dc.contributor.authorLim, DS-
dc.contributor.authorRha, SW-
dc.contributor.authorLee, SG-
dc.contributor.authorGwon, HC-
dc.contributor.authorKim, HS-
dc.contributor.authorChae, IH-
dc.contributor.authorJang, Y-
dc.contributor.authorJeong, MH-
dc.contributor.authorTahk, SJ-
dc.contributor.authorSeung, KB-
dc.contributor.authorPark, SJ-
dc.date.accessioned2017-03-28T05:50:47Z-
dc.date.available2017-03-28T05:50:47Z-
dc.date.issued2015-
dc.identifier.issn0735-1097-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13658-
dc.description.abstractBACKGROUND: In a previous randomized trial, we found that percutaneous coronary intervention (PCI) was not inferior to coronary artery bypass grafting (CABG) for the treatment of unprotected left main coronary artery stenosis at 1 year.

OBJECTIVES: This study sought to determine the 5-year outcomes of PCI compared with CABG for the treatment of unprotected left main coronary artery stenosis.

METHODS: We randomly assigned 600 patients with unprotected left main coronary artery stenosis to undergo PCI with a sirolimus-eluting stent (n = 300) or CABG (n = 300). The primary endpoint was a major adverse cardiac or cerebrovascular event (MACCE: a composite of death from any cause, myocardial infarction, stroke, or ischemia-driven target vessel revascularization) and compared on an intention-to-treat basis.

RESULTS: At 5 years, MACCE occurred in 52 patients in the PCI group and 42 patients in the CABG group (cumulative event rates of 17.5% and 14.3%, respectively; hazard ratio [HR]: 1.27; 95% confidence interval [CI]: 0.84 to 1.90; p = 0.26). The 2 groups did not differ significantly in terms of death from any cause, myocardial infarction, or stroke as well as their composite (8.4% and 9.6%; HR, 0.89; 95% CI, 0.52 to 1.52; p = 0.66). Ischemia-driven target vessel revascularization occurred more frequently in the PCI group than in the CABG group (11.4% and 5.5%, respectively; HR: 2.11; 95% CI: 1.16 to 3.84; p = 0.012).

CONCLUSIONS: During 5 years of follow-up, our study did not show significant difference regarding the rate of MACCE between patients who underwent PCI with a sirolimus-eluting stent and those who underwent CABG. However, considering the limited power of our study, our results should be interpreted with caution. (Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease [PRECOMBAT]; NCT00422968).
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHCoronary Artery Bypass-
dc.subject.MESHCoronary Artery Disease-
dc.subject.MESHCoronary Stenosis-
dc.subject.MESHDrug-Eluting Stents-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPercutaneous Coronary Intervention-
dc.subject.MESHProspective Studies-
dc.subject.MESHSirolimus-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleRandomized Trial of Stents Versus Bypass Surgery for Left Main Coronary Artery Disease: 5-Year Outcomes of the PRECOMBAT Study.-
dc.typeArticle-
dc.identifier.pmid25787197-
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0735-1097(15)00841-4-
dc.contributor.affiliatedAuthor탁, 승제-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.jacc.2015.03.033-
dc.citation.titleJournal of the American College of Cardiology-
dc.citation.volume65-
dc.citation.number20-
dc.citation.date2015-
dc.citation.startPage2198-
dc.citation.endPage2206-
dc.identifier.bibliographicCitationJournal of the American College of Cardiology, 65(20). : 2198-2206, 2015-
dc.identifier.eissn1558-3597-
dc.relation.journalidJ007351097-
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Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
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