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Long-Term Patient-Related and Lesion-Related Outcomes After Real-World Fractional Flow Reserve Use.

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dc.contributor.authorDoh, JH-
dc.contributor.authorNam, CW-
dc.contributor.authorKoo, BK-
dc.contributor.authorPark, SH-
dc.contributor.authorLee, JH-
dc.contributor.authorHan, JK-
dc.contributor.authorYang, HM-
dc.contributor.authorLim, HS-
dc.contributor.authorYoon, MH-
dc.contributor.authorCho, YK-
dc.contributor.authorHur, SH-
dc.contributor.authorLee, SY-
dc.contributor.authorKim, HS-
dc.contributor.authorTahk, SJ-
dc.date.accessioned2017-03-28T06:14:06Z-
dc.date.available2017-03-28T06:14:06Z-
dc.date.issued2015-
dc.identifier.issn1042-3931-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13661-
dc.description.abstractBACKGROUND: Long-term clinical outcomes of real-world use of fractional flow reserve (FFR), including the decisions against FFR, have not been fully evaluated in the era of drug-eluting stent (DES) implantation.

METHODS: A total of 1294 patients who underwent FFR measurement for de novo coronary lesions were included. FFR measured lesions (n = 1628) were divided into FFR-defer or FFR-stent lesions according to the treatment strategy selected after FFR measurement. Clinical outcomes were assessed by patient-related major adverse cardiac event (a composite of all-cause death, myocardial infarction, and any revascularization) and target-lesion related event (target-lesion related myocardial infarction and revascularization).

RESULTS: Mean FFR was 0.80 ± 0.12, and FFR was ≤0.8 in 728 lesions (44.7%). Five-year cumulative all-death rate was 6.3%, myocardial infarction rate was 1.5%, and rate of any revascularization was 12.5%. Among 797 deferred lesions, 105 lesions had FFR ≤0.8 and those lesions had a higher risk of 5-year target-lesion related events than the lesions with FFR >0.8 (21.2% vs 6.6%, respectively; P=.03). By multivariate analyses, the determinant for the 1-year target-lesion related events was the presence of diabetes (hazard ratio, 3.74; 95% confidence interval, 1.45-9.67; P=.01), while the determinant for delayed events at 1-5 years was FFR ≤0.8 (hazard ratio, 4.50; 95% confidence interval, 1.65-12.28; P=.01). Angiographic lesion severity was not an independent predictor for clinical events during follow-up among deferred lesions.

CONCLUSION: The deferral of stenting according to FFR was associated with favorable long-term outcomes. Presence of diabetes and low FFR (≤0.8) increased the risk of clinical events in deferred lesions.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHAngioplasty, Balloon, Coronary-
dc.subject.MESHCause of Death-
dc.subject.MESHCoronary Angiography-
dc.subject.MESHCoronary Artery Disease-
dc.subject.MESHDiabetes Mellitus-
dc.subject.MESHFemale-
dc.subject.MESHFractional Flow Reserve, Myocardial-
dc.subject.MESHHumans-
dc.subject.MESHLong Term Adverse Effects-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMortality-
dc.subject.MESHMyocardial Infarction-
dc.subject.MESHMyocardial Revascularization-
dc.subject.MESHPatient Outcome Assessment-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Assessment-
dc.subject.MESHStents-
dc.titleLong-Term Patient-Related and Lesion-Related Outcomes After Real-World Fractional Flow Reserve Use.-
dc.typeArticle-
dc.identifier.pmid26332875-
dc.identifier.urlhttp://www.invasivecardiology.com/articles/long-term-patient-related-and-lesion-related-outcomes-after-real-world-fractional-flow-
dc.contributor.affiliatedAuthor임, 홍석-
dc.contributor.affiliatedAuthor윤, 명호-
dc.contributor.affiliatedAuthor탁, 승제-
dc.type.localJournal Papers-
dc.citation.titleThe Journal of invasive cardiology-
dc.citation.volume27-
dc.citation.number9-
dc.citation.date2015-
dc.citation.startPage410-
dc.citation.endPage415-
dc.identifier.bibliographicCitationThe Journal of invasive cardiology, 27(9). : 410-415, 2015-
dc.identifier.eissn1557-2501-
dc.relation.journalidJ010423931-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
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