Cited 0 times in Scipus Cited Count

Utility of the rio score and modified rio score in korean patients with multiple sclerosis.

Hyun, JW | Kim, SH | Jeong, IH | Ahn, SW | Huh, SY | Park, MS | Eom, YI  | Joo, IS  | Cho, JY | Cho, EB | Min, JH | Kim, BJ | Kim, NH | Oh, J | Park, KD | Kim, HJ
PloS one, 10(5). : e0129243-e0129243, 2015
Journal Title
PloS one
OBJECTIVES: Early identification of suboptimal responders to multiple sclerosis (MS) treatment is critical for optimizing therapeutic decisions. The Rio score (RS) and modified Rio score (MRS) were developed to discriminate the responses to interferon-beta (IFNB) treatment in MS patients. This study was performed to evaluate the utility of RS and MRS in daily clinical practice in Korea.

METHODS: This was a real-world setting, multicenter, retrospective study of MS patients treated with IFNB from 10 hospitals in Korea. We investigated whether the RS and MRS at the early stage of IFNB therapy could predict treatment responses over 3 years. Suboptimal treatment responses at 3 years were defined as the presence of clinical relapse and/or EDSS progression and/or patients who had been treated with INFB for at least for 1 year and therapy was switched due to perceived treatment failure during the 2 years of follow-up.

RESULTS: Seventy patients (50 females and 20 males) were enrolled; 92% (12/13) of patients with high RS and 86% (12/14) of patients with high MRS (score 2 or 3) were suboptimal responders, whereas 93% (53/57) of patients with low RS and 93% (52/56) patients with low MRS (score 0 or 1) showed optimal responses. New active lesions on MRI with clinical relapse in high RS and MRS were the most common combination in suboptimal responders.

CONCLUSIONS: We confirmed that RS and MRS at 6-15 months of IFNB therapy were useful for predicting poor responders over 3 years.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Ajou Authors
엄, 영인  |  주, 인수
Full Text Link
Files in This Item:


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.