Cited 0 times in Scipus Cited Count

Impaired vascular endothelial function in patients with restless legs syndrome: a new aspect of the vascular pathophysiology.

DC Field Value Language
dc.contributor.authorKoh, SY-
dc.contributor.authorKim, MS-
dc.contributor.authorLee, SM-
dc.contributor.authorHong, JM-
dc.contributor.authorYoon, JH-
dc.date.accessioned2017-03-29T06:04:29Z-
dc.date.available2017-03-29T06:04:29Z-
dc.date.issued2015-
dc.identifier.issn0022-510X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13682-
dc.description.abstractBACKGROUND: Restless legs syndrome (RLS) is a common sleep disorder in which patients feel unpleasant leg sensations and the urge to move their legs during rest, particularly at night. Leg movement improves these symptoms. Although several studies have demonstrated an association between cardiovascular disease and RLS, the mechanisms underlying this relationship remain unclear. Recent studies have shown changes in the peripheral microvasculature, including altered blood flow and capillary tortuosity, and peripheral hypoxia. Vascular endothelial dysfunction can be assessed noninvasively with ultrasound measurements of brachial artery flow-mediated dilatation (FMD). Therefore, this study investigated FMD in RLS patients to determine the involvement of microvascular alterations in this disorder.

METHODS: The study enrolled 25 drug-naïve RLS patients and 25 sex- and age-matched controls and compared the FMD values of the two groups. RLS was diagnosed according to the criteria of the International Restless Legs Syndrome Study Group.

RESULTS: FMD was significantly lower in the RLS patients (6.6 ± 1.2%) compared to the controls (8.4 ± 1.8%; p<0.05) and the RLS patients showed a weak, negative correlation between RLS severity and FMD (r=-0.419, p=0.04). Multivariate linear regression analysis revealed that RLS (B=-1.87, 95% confidence interval [CI] -2.72 to -1.02; p<0.001) and age (B=-0.06; 95% CI -0.12 to -0.02; p<0.001) were significantly and inversely correlated with FMD.

CONCLUSIONS: This study demonstrated that RLS patients have poorer vascular endothelial function than normal healthy subjects and provides further evidence supporting the involvement of peripheral systems in the generation of RLS.
-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBrachial Artery-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyperthermia, Induced-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRestless Legs Syndrome-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStatistics, Nonparametric-
dc.subject.MESHSubclavian Steal Syndrome-
dc.subject.MESHUltrasonography-
dc.titleImpaired vascular endothelial function in patients with restless legs syndrome: a new aspect of the vascular pathophysiology.-
dc.typeArticle-
dc.identifier.pmid26671114-
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0022-510X(15)02533-2-
dc.contributor.affiliatedAuthor홍, 지만-
dc.contributor.affiliatedAuthor윤, 정한-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.jns.2015.10.041-
dc.citation.titleJournal of the neurological sciences-
dc.citation.volume359-
dc.citation.number1-2-
dc.citation.date2015-
dc.citation.startPage207-
dc.citation.endPage210-
dc.identifier.bibliographicCitationJournal of the neurological sciences, 359(1-2). : 207-210, 2015-
dc.identifier.eissn1878-5883-
dc.relation.journalidJ00022510X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse