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Eight hours of nocturnal 915 MHz radiofrequency identification (RFID) exposure reduces urinary levels of melatonin and its metabolite via pineal arylalkylamine N-acetyltransferase activity in male rats.

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dc.contributor.authorKim, HS-
dc.contributor.authorPaik, MJ-
dc.contributor.authorLee, YH-
dc.contributor.authorLee, YS-
dc.contributor.authorChoi, HD-
dc.contributor.authorPack, JK-
dc.contributor.authorKim, N-
dc.contributor.authorAhn, YH-
dc.date.accessioned2017-03-29T06:24:01Z-
dc.date.available2017-03-29T06:24:01Z-
dc.date.issued2014-
dc.identifier.issn0955-3002-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13685-
dc.description.abstractPURPOSE: We investigated the effects of whole-body exposure to the 915 MHz radiofrequency identification (RFID) on melatonin biosynthesis and the activity of rat pineal arylalkylamine N-acetyltransferase (AANAT).

MATERIALS AND METHODS: Rats were exposed to RFID (whole-body specific absorption rate, 4 W/kg) for 8 h/day, 5 days/week, for weeks during the nighttime. Total volume of urine excreted during a 24-h period was collected after RFID exposure. Urinary melatonin and 6-hydroxymelatonin sulfate (6-OHMS) was measured by gas chromatography-mass spectrometry (GC-MS) and enzyme-linked immunosorbent assay (ELISA), respectively. AANAT enzyme activity was measured using liquid biphasic dif-13 fusion assay. Protein levels and mRNA expression of AANAT was 14 measured by Western blot and reverse transcription polymerase 15 chain reaction (RT-PCR) analysis, respectively.

RESULTS: Eight hours of nocturnal RFID exposure caused a significant reduction in both urinary melatonin (p = 0. 003) and 6-OHMS (p = 0. 026). Activity, protein levels, and mRNA expression of AANAT were suppressed by exposure to RFID (p < 0. 05).

CONCLUSIONS: Our results suggest that nocturnal RFID exposure can cause reductions in the levels of both urinary melatonin and 6-OHMS, possibly due to decreased melatonin biosynthesis via suppression of Aanat gene transcription in the rat pineal gland.
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dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHArylalkylamine N-Acetyltransferase/metabolism-
dc.subject.MESHEnzyme Activation/radiation effects-
dc.subject.MESHMale-
dc.subject.MESHMelatonin/analogs & derivatives-
dc.subject.MESHMelatonin/urine-
dc.subject.MESHPineal Gland/metabolism-
dc.subject.MESHPineal Gland/radiation effects-
dc.subject.MESHRadiation Dosage-
dc.subject.MESHRadiation Exposure-
dc.subject.MESHRadio Frequency Identification Device-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHWhole-Body Irradiation-
dc.titleEight hours of nocturnal 915 MHz radiofrequency identification (RFID) exposure reduces urinary levels of melatonin and its metabolite via pineal arylalkylamine N-acetyltransferase activity in male rats.-
dc.typeArticle-
dc.identifier.pmid26189731-
dc.identifier.urlhttp://www.tandfonline.com/doi/full/10.3109/09553002.2015.1075075-
dc.contributor.affiliatedAuthor김, 혜선-
dc.contributor.affiliatedAuthor안, 영환-
dc.type.localJournal Papers-
dc.identifier.doi10.3109/09553002.2015.1075075-
dc.citation.titleInternational journal of radiation biology-
dc.citation.volume91-
dc.citation.number11-
dc.citation.date2014-
dc.citation.startPage898-
dc.citation.endPage907-
dc.identifier.bibliographicCitationInternational journal of radiation biology, 91(11). : 898-907, 2014-
dc.identifier.eissn1362-3095-
dc.relation.journalidJ009553002-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
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