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Immunologic evaluation of patients with cefotetan-induced anaphylaxis.

Authors
Nam, YH | Hwang, EK | Ban, GY  | Jin, HJ | Yoo, HS  | Shin, YS  | Ye, YM  | Nahm, DH  | Park, HS  | Lee, SK
Citation
Allergy, asthma & immunology research, 7(3). : 301-303, 2015
Journal Title
Allergy, asthma & immunology research
ISSN
2092-73552092-7363
Abstract
Cefotetan is a commonly prescribed second-generation cephalosporin that acts against a wide range of bacteria. However, cefotetan-induced hypersensitivity has rarely been reported. We report 2 cases of cefotetan-induced anaphylaxis with immunologic evaluation. The first case was a 70-year-old asthmatic woman who had dyspnea and hypotension during administration of cefotetan, in which high serum-specific IgE to cefotetan-human serum albumin (HSA) conjugate was detected by enzyme-linked immunosorbent assay. The second case was a 63-year-old asthmatic woman who complained of chest tightness and dyspnea during cefotetan infusion, in which high serum-specific IgG1 and IgG4 with no serum specific IgE to cefotetan-HSA conjugate was detected. The basophil activation test using basophils from the patient showed a significant up-regulation of CD63 with the addition of anti-IgG4 antibody compared with that in non-atopic healthy controls. In conclusion, cefotetan can induce anaphylaxis, which may involve both IgE- and IgG4-mediated responses in the pathogenic mechanism.
Keywords

DOI
10.4168/aair.2015.7.3.301
PMID
25749763
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Ajou Authors
남, 동호  |  박, 해심  |  반, 가영  |  신, 유섭  |  예, 영민  |  유, 혜수
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