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A prospective, multicenter study of a double stent system for palliative treatment of malignant extrahepatic biliary obstructions.

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dc.contributor.authorKim, JW-
dc.contributor.authorGwon, D-
dc.contributor.authorHan, YM-
dc.contributor.authorWon, JH-
dc.contributor.authorHong, HP-
dc.contributor.authorKo, GY-
dc.contributor.authorYoon, HK-
dc.contributor.authorSung, KB-
dc.date.accessioned2017-04-06T02:36:20Z-
dc.date.available2017-04-06T02:36:20Z-
dc.date.issued2015-
dc.identifier.issn0284-1851-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13799-
dc.description.abstractBACKGROUND: A double stent system (covered stent in uncovered stent) was designed to provide long-term patency without tumor ingrowth or stent-related complications, such as stent migration, cholecystitis, or pancreatitis.

PURPOSE: To investigate the safety and efficacy of double stents in patients with malignant extrahepatic biliary obstructions.

MATERIAL AND METHODS: This prospective, nonrandomized, multicenter study enrolled 160 consecutive patients (102 men; mean age, 64 years; range, 33-91 years) with malignant extrahepatic biliary obstructions treated with a double stent system from January 2010 to March 2012.

RESULTS: The technical success rate of the double stent placement was 100%. No stent migration was observed. Procedure-related minor (self-limiting hemobilia [n = 6] and cholangitis [n = 2]) and major (pancreatitis [n = 16], cholecystitis [n = 3], and hepatic abscess [n = 2]) complications occurred in a total of 29 patients. The mean serum bilirubin level, which was 8.9 ± 5.6 mg/dL before drainage, decreased to 2.2 ± 4.6 mg/dL 1 month after stent placement (P < 0.001). Successful internal drainage was achieved in 148 patients (92.5%). During the mean follow-up period of 205 days, acute cholecystitis (n = 3) and hepatic abscess (n = 2) occurred in five patients. The median patient survival and stent patency time were 135 days (95% confidence interval [CI], 96-160 days) and 114 days (95% CI, 83-131 days), respectively. Of 153 patients, 22 (14.4%) presented with stent dysfunction due to sludge incrustation (n = 17), tumor overgrowth (n = 4), or blood clot (n = 1), and required repeat intervention. Tumor ingrowth was not observed in any of these patients.

CONCLUSION: Percutaneous treatment of malignant extrahepatic biliary obstruction using a double stent safely and effectively achieves internal biliary drainage.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBile Duct Neoplasms-
dc.subject.MESHCholestasis-
dc.subject.MESHDrainage-
dc.subject.MESHEquipment Design-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPalliative Care-
dc.subject.MESHProspective Studies-
dc.subject.MESHStents-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.titleA prospective, multicenter study of a double stent system for palliative treatment of malignant extrahepatic biliary obstructions.-
dc.typeArticle-
dc.identifier.pmid25260418-
dc.identifier.urlhttp://journals.sagepub.com/doi/abs/10.1177/0284185114550702?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed-
dc.contributor.affiliatedAuthor원, 제환-
dc.type.localJournal Papers-
dc.identifier.doi10.1177/0284185114550702-
dc.citation.titleActa radiologica (Stockholm, Sweden : 1987)-
dc.citation.volume56-
dc.citation.number10-
dc.citation.date2015-
dc.citation.startPage1209-
dc.citation.endPage1215-
dc.identifier.bibliographicCitationActa radiologica (Stockholm, Sweden : 1987), 56(10). : 1209-1215, 2015-
dc.identifier.eissn1600-0455-
dc.relation.journalidJ002841851-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
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