Cited 0 times in Scipus Cited Count

The relationship between cognitive performance and insulin resistance in non-diabetic patients with mild cognitive impairment.

DC Field Value Language
dc.contributor.authorKim, TE-
dc.contributor.authorLee, DH-
dc.contributor.authorKim, YJ-
dc.contributor.authorMok, JO-
dc.contributor.authorKim, CH-
dc.contributor.authorPark, JH-
dc.contributor.authorLee, TK-
dc.contributor.authorYoo, K-
dc.contributor.authorJeong, Y-
dc.contributor.authorLee, Y-
dc.contributor.authorPark, SA-
dc.date.accessioned2017-04-07T02:52:44Z-
dc.date.available2017-04-07T02:52:44Z-
dc.date.issued2015-
dc.identifier.issn0885-6230-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13820-
dc.description.abstractOBJECTIVE: Insulin resistance (IR) is a distinct and early feature of type 2 diabetes mellitus and metabolic syndrome. IR is thought to play a vital role in cognitive impairment. We conducted this study to understand the early characteristics of cognitive dysfunctions attributable to IR.

METHODS: This study included 85 consecutive non-diabetic elderly participants with mild cognitive impairment (MCI). IR was estimated with the homeostasis model assessment of insulin resistance (HOMA-IR). Cognitive performances were analyzed as a function of scores on the HOMA-IR.

RESULTS: The group analysis those with and without IR did not show any differences in the cognitive performance although higher HOMA-IR was closely associated with lower performances in immediate recall on the Seoul Verbal Learning Test (SVLT-I) (r = -0.244, p = 0.026) and Controlled Oral Word Association Test (COWAT) (r = -0.270, p = 0.013). In subgroup analysis by APOE status, SVLT-delayed (p = 0.027) and COWAT (p = 0.016) scores were found to be significantly lower in the IR than the non-IR among those with APOE ε4 allele. In multiple regression analysis, impairment on the COWAT remained significantly correlated with scores on HOMA-IR (β = -0.271, t = -2.340, p = 0.022). However, IR status was identified to interact with APOE ε4 carriership toward poor performances in the COWAT (β = -0.335, t = -2.285, p = 0.026).

CONCLUSION: This study found a domain-specific impact of HOMA-IR scores on cognitive performances in non-diabetic patients with MCI. This association was profound only in APOE ε4carriers.
-
dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHApolipoprotein E4-
dc.subject.MESHCognition-
dc.subject.MESHCognitive Dysfunction-
dc.subject.MESHFemale-
dc.subject.MESHHomeostasis-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance-
dc.subject.MESHMale-
dc.subject.MESHModels, Biological-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHRegression Analysis-
dc.titleThe relationship between cognitive performance and insulin resistance in non-diabetic patients with mild cognitive impairment.-
dc.typeArticle-
dc.identifier.pmid25060738-
dc.contributor.affiliatedAuthor이, 윤환-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/gps.4181-
dc.citation.titleInternational journal of geriatric psychiatry-
dc.citation.volume30-
dc.citation.number6-
dc.citation.date2015-
dc.citation.startPage551-
dc.citation.endPage557-
dc.identifier.bibliographicCitationInternational journal of geriatric psychiatry, 30(6). : 551-557, 2015-
dc.identifier.eissn1099-1166-
dc.relation.journalidJ008856230-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse