76 635

Cited 4 times in

Severity of White Matter Hyperintensities and Length of Hospital Stay in Patients with Cognitive Impairment: A CREDOS (Clinical Research Center for Dementia of South Korea) Study.

Authors
Chang, KJ  | Lee, S | Lee, Y  | Lee, KS | Back, JH | Jung, YK  | Lim, KY  | Noh, JS  | Kim, HC | Roh, HW | Choi, SH | Kim, SY | Son, SJ  | Hong, CH
Citation
Journal of Alzheimer's disease : JAD, 46(3). : 719-726, 2015
Journal Title
Journal of Alzheimer's disease : JAD
ISSN
1387-28771875-8908
Abstract
BACKGROUND & OBJECTIVE: White matter hyperintensities (WMHs) contribute to aggravation of dementia or geriatric syndrome, thereby resulting in functional impairment. However, evidence of direct association between WMHs and medical resource utilization indicated by length of hospital stay (LOS) is scarce in patients with cognitive impairment. This study aimed to examine the relationship between the severity of WMHs and LOS in patients with cognitive impairment.

METHODS: 4,253 older adults with cognitive impairment were enrolled in this study. We defined LOS as the total sum of days from January 1, 2008 to December 31, 2012. The severity of periventricular (PVWMHs), deep (DWMHs), and overall white matter hyperintensities (Overall WMHs) was evaluated by a visual rating scale. We conducted multinomial logistic regression to demonstrate the relationship between LOS and severity of PVWHMs, DWHMs, and Overall WMHs, respectively.

RESULTS: The median LOS was 20 days. Severe PVWMHs had a higher likelihood of longer LOS (Q3: odd ratio/OR = 1.32, 95% confidence interval/CI = 1.06-1.64; Q4: OR = 1.33, 95% CI = 1.07-1.65; Q5: OR = 1.55, 95% CI = 1.26-1.91). As for DWMHs, moderate DWMHs were related to longer LOS (Q4: OR = 1.33, 95% CI = 1.03-1.71; Q5: OR = 1.63, 95% CI = 1.26-2.11). Finally, severity of overall WMHs was independently associated with LOS, which was similar to the results of DWMHs.

CONCLUSION: These findings would advocate for prevention of WMHs to stave off excess medical resource utilization in patients with cognitive impairment.
MeSH

DOI
10.3233/JAD-142823
PMID
25854927
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
Ajou Authors
노, 재성  |  손, 상준  |  이, 윤환  |  임, 기영  |  장, 기중  |  정, 영기  |  홍, 창형
Full Text Link
Files in This Item:
There are no files associated with this item.
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse