189 571

Cited 10 times in

Increased plasma levels of heat shock protein 70 associated with subsequent clinical conversion to mild cognitive impairment in cognitively healthy elderly.

Authors
Son, SJ  | Lee, KS | Chung, JH | Chang, KJ  | Roh, HW | Kim, SH | Jin, T | Back, JH | Kim, HJ | Lee, Y  | Choi, SH | Noh, JS  | Lim, KY  | Chung, YK  | Hong, CH  | Oh, BH
Citation
PloS one, 10(3). : e0119180-e0119180, 2015
Journal Title
PloS one
ISSN
1932-6203
Abstract
BACKGROUND AND AIMS: Heat shock proteins (HSPs) have been regarded as cytoprotectants that protect brain cells during the progression of neurodegenerative diseases and from damage resulting from cerebral ischemia. In this study, we assessed the association between plasma HSP 70/27 levels and cognitive decline.

METHODS: Among participants in the community-based cohort study of dementia called the Gwangju Dementia and Mild Cognitive Impairment Study, subjects without cognitive impairment at baseline, who then either remained without impairment (non-conversion group), or suffered mild cognitive impairment (MCI) (conversion group) (non-conversion group, N = 36; conversion group, N = 30) were analyzed.

RESULTS: After a five to six year follow-up period, comparison of the plasma HSP 70 and HSP 27 levels of the two groups revealed that only the plasma HSP 70 level was associated with a conversion to MCI after adjustments for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (repeated measure analysis of variance: F = 7.59, p = 0.008). Furthermore, an increase in plasma HSP 70 level was associated with cognitive decline in language and executive function (linear mixed model: Korean Boston Naming Test, -0.426 [-0.781, -0.071], p = 0.019; Controlled Oral Word Association Test, -0.176 [-0.328, -0.023], p = 0.024; Stroop Test, -0.304 [-0.458, -0.150], p<0.001).

CONCLUSIONS: These findings suggest that the plasma HSP 70 level may be related to cognitive decline in the elderly.
MeSH

DOI
10.1371/journal.pone.0119180
PMID
25768018
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
Ajou Authors
노, 재성  |  손, 상준  |  이, 윤환  |  임, 기영  |  장, 기중  |  정, 영기  |  홍, 창형
Full Text Link
Files in This Item:
25768018.pdfDownload
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse