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Effect of hypertension on the resting-state functional connectivity in patients with Alzheimer's disease (AD).

DC Field Value Language
dc.contributor.authorSon, SJ-
dc.contributor.authorKim, J-
dc.contributor.authorLee, E-
dc.contributor.authorPark, JY-
dc.contributor.authorNamkoong, K-
dc.contributor.authorHong, CH-
dc.contributor.authorKu, J-
dc.contributor.authorKim, E-
dc.contributor.authorOh, BH-
dc.date.accessioned2017-05-08T06:45:36Z-
dc.date.available2017-05-08T06:45:36Z-
dc.date.issued2015-
dc.identifier.issn0167-4943-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/13990-
dc.description.abstractBACKGROUND/OBJECTIVES: Although hypertension is known to be a risk factor for AD, the effects of hypertension on brain function in AD patients are not well understood. We investigated alterations in resting-state functional connectivity according to the presence of hypertension in AD patients by using a method of correlation analysis based on a seed region in the posterior cingulate cortex (PCC). We also determined whether differences in resting-state connectivity were associated with gray matter atrophy.

METHODS: Thirty-seven AD patients (18 patients with hypertension and 19 patients without hypertension) underwent the resting-state functional magnetic resonance imaging. We obtained the PCC maps by a temporal correlation method, to identify alterations in the functional connectivity of the PCC in hypertensive group relative to non-hypertensive group. Voxel-based morphometry analysis was also applied to adjust the confounding effect of gray matter atrophy.

RESULTS: We detected a decreased connectivity to the PCC in the regions of subgenual anterior cingulated cortex (ACC) in hypertensive group relative to non-hypertensive group. However, we observed a pattern of increased connectivity between the PCC and the left inferior parietal cortex in hypertensive group. After correction for gray matter atrophy, all detected regions still remained significant.

CONCLUSIONS: Altered connectivity in AD patients with hypertension suggests the possibility that hypertension impairs resting-state functional connectivity of the AD brain, inducing a compensational process outside the impaired networks or disequilibrium in brain connectivity. This finding may account for an additional contribution of hypertension to the pathophysiology of AD.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHAlzheimer Disease-
dc.subject.MESHAtrophy-
dc.subject.MESHBrain-
dc.subject.MESHBrain Mapping-
dc.subject.MESHCerebral Cortex-
dc.subject.MESHFemale-
dc.subject.MESHFunctional Laterality-
dc.subject.MESHGyrus Cinguli-
dc.subject.MESHHumans-
dc.subject.MESHHypertension-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.titleEffect of hypertension on the resting-state functional connectivity in patients with Alzheimer's disease (AD).-
dc.typeArticle-
dc.identifier.pmid25307953-
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0167-4943(14)00179-4-
dc.contributor.affiliatedAuthor손, 상준-
dc.contributor.affiliatedAuthor홍, 창형-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.archger.2014.09.012-
dc.citation.titleArchives of gerontology and geriatrics-
dc.citation.volume60-
dc.citation.number1-
dc.citation.date2015-
dc.citation.startPage210-
dc.citation.endPage216-
dc.identifier.bibliographicCitationArchives of gerontology and geriatrics, 60(1). : 210-216, 2015-
dc.identifier.eissn1872-6976-
dc.relation.journalidJ001674943-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
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