227 180

Cited 0 times in

The role of tubulin in ganglioside-induced ramifications in cultured rat brain microglia

Other Title
Gangliosides 자극에 의한 신경소교세포의 형태학적 변화에서의 tubulin의 역할에 대한 연구
Authors
박, 지영
Degree
Master (2006)
Abstract
"In addition to functional changes, activated microglia undergo morphological changes from a resting, ramified morphology to an activated, amoeboid shape. Gangliosides, despite their role as microglial activators, induce microglial ramifications. To identify the cytoskeletal components involved in microglial ramification, we stimulated cells with gangliosides in the absence or presence of cytoskeletal inhibitors and examined the resultant morphological changes. While LPS-induced ameboid shapes were blocked by all inhibitors, actin inhitibors and microtubule inhibitor, Ganglioside-induced ramifications were blocked by either paclitaxel or nocodazole, inhibitors of microtubule, but not by cytochalasin B or latrunculin B, which are inhibitors of actin polymerization. In contrast to these morphological changes, iNOS expression was suppressed by both inhibitors of actin filament and inhibitors of microtubule. These results indicate that ganglioside-induced ramification is more dependent on tubulin than actin and that both of these cytoskeletal components are involved in iNOS expression. "
Keywords
tubulinactingangliosidesmicrogliaramification
Appears in Collections:
Theses > School of Medicine / Graduate School of Medicine > Master
AJOU Authors
박지영
Full Text Link
Files in This Item:
000000001228.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse