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Recurrence Risk-Scoring Model for Stage I Adenocarcinoma of the Lung.

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dc.contributor.authorYang, HC-
dc.contributor.authorKim, HR-
dc.contributor.authorJheon, S-
dc.contributor.authorKim, K-
dc.contributor.authorCho, S-
dc.contributor.authorAhn, S-
dc.contributor.authorLee, HY-
dc.contributor.authorChung, JH-
dc.contributor.authorChung, KY-
dc.contributor.authorBae, MK-
dc.contributor.authorPark, SY-
dc.contributor.authorKim, DK-
dc.contributor.authorChoi, SH-
dc.contributor.authorZo, JI-
dc.contributor.authorKim, MS-
dc.contributor.authorLee, JM-
dc.contributor.authorKim, J-
dc.contributor.authorShim, YM-
dc.contributor.authorNa, KJ-
dc.contributor.authorYun, JS-
dc.contributor.authorPark, JY-
dc.date.accessioned2017-06-14T05:54:40Z-
dc.date.available2017-06-14T05:54:40Z-
dc.date.issued2015-
dc.identifier.issn1068-9265-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/14170-
dc.description.abstractPURPOSE: The aim of this retrospective, multicenter study was to develop a recurrence risk-scoring model in patients with curatively resected stage I lung adenocarcinoma (ADC).

METHODS: Clinicopathologic and outcome data for a development cohort of 1,700 patients with pathologic stage I ADC from four institutions resected between January 2000 and December 2009 were evaluated. A phantom study was performed for correction of inter-institutional differences in positron emission tomography-standardized uptake value (PET-SUV). A nomogram for recurrence prediction was developed using Cox proportional hazards regression. This model was validated in a cohort of 460 patients in two other hospitals. The recurrence rate was 21.0 % for the development cohort and 22.1 % for the validation cohort.

RESULTS: In multivariable analysis, three independent predictors for recurrence were identified: pathologic tumor size (hazard ratio [HR] 1.03, 95 % CI 1.017-1.048; p < 0.001), corrected PET-SUV (HR 1.08, 95 % CI 1.051-1.105; p < 0.001), and lymphovascular invasion (HR 1.65, 95 % CI 1.17-2.33; p = 0.004). The nomogram was made based on these factors and a calculated risk score was accorded to each patient. Kaplan-Meier analysis of the development cohort showed a 5-year recurrence-free survival (RFS) of 83 % (95 % CI 0.80-0.86) in low-risk patients and 59 % (95 % CI 0.54-0.66) in high-risk patients with the highest 30 percentile scores. The concordance index was 0.632 by external validation.

CONCLUSIONS: This recurrence risk-scoring model can be used to predict the RFS for pathologic stage I ADC patients using the above three easily measurable factors. High-risk patients need close follow-up and can be candidates for adjuvant chemotherapy.
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dc.language.isoen-
dc.subject.MESHAdenocarcinoma-
dc.subject.MESHAged-
dc.subject.MESHBlood Vessels-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms-
dc.subject.MESHLymphatic Vessels-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHNomograms-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHTumor Burden-
dc.titleRecurrence Risk-Scoring Model for Stage I Adenocarcinoma of the Lung.-
dc.typeArticle-
dc.identifier.pmid25783676-
dc.contributor.affiliatedAuthor박, 성용-
dc.type.localJournal Papers-
dc.identifier.doi10.1245/s10434-015-4411-9-
dc.citation.titleAnnals of surgical oncology-
dc.citation.volume22-
dc.citation.number12-
dc.citation.date2015-
dc.citation.startPage4089-
dc.citation.endPage4097-
dc.identifier.bibliographicCitationAnnals of surgical oncology, 22(12). : 4089-4097, 2015-
dc.identifier.eissn1534-4681-
dc.relation.journalidJ010689265-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Thoracic & Cardiovascular Surgery
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