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Age-Related Changes and Regional Variations in Three-Dimensional Microstructural Properties of Male Proximal Femoral Trabecular Bone

Other Title
인간 대퇴골 근위부의 3차원적 골소주 미세구조에서 연령에 따른 변화와 부위에 따른 차이
Authors
최, 문권
Degree
Doctor (2007)
Abstract
"Purpose: The purpose of this study was therefore to explore regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging.

Materials and Methods: A total of 162 trabecular bone cores were obtained from six regions (femoral head, superior and inferior regions of the neck, and superior/middle and inferior regions of the trochanter) of twenty-seven normal femora of Korean male cadaver donors, aged 40-90 years. These specimens were scanned using high-resolution micro-computed tomography (micro-CT). The following 3D microstructural parameters were calculated: bone volume fraction (BV/TV), trabecular thickness (Tb.Th), separation (Tb.Sp) and number (Tb.N), structure model index (SMI) and degree of anisotropy (DOA).

Results: The results showed that the trabecular microstructure changed significantly with age, as well as varied from different regions of the proximal femur. There was a significant decrease in bone volume fraction and an almost identical decrease in trabecular thickness associated with aging at any region. Regional analysis demonstrated a significant difference not only in BV/TV, Tb.Th, Tb.Sp, Tb.N, DOA between superior and inferior neck, but also difference in BV/TV, Tb.Sp, Tb.N, SMI, DOA between superior and inferior trochanter.

Conclusions: Age-related changes in bone loss and trabecular microstructure within the male proximal femur are not uniform in this Korean cadaveric population. As a result of mechanical and age-related adaptation, significant regional variations in microstructural properties of trabecular bone are likely to be an important factor affecting the mechanical properties of the proximal femur.

"
Keywords
AgingMicrostructureTrabeculaeProximal femur
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Theses > School of Medicine / Graduate School of Medicine > Doctor
AJOU Authors
최, 문권
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