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Clinical Significance of the Endoscopic Finding in Predicting Complete Tumor Response to Preoperative Chemoradiation Therapy in Rectal Cancer

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dc.contributor.authorLim, SG-
dc.contributor.authorKim, YB-
dc.contributor.authorOh, SY-
dc.date.accessioned2018-05-04T00:24:10Z-
dc.date.available2018-05-04T00:24:10Z-
dc.date.issued2016-
dc.identifier.issn0364-2313-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/14815-
dc.description.abstractBACKGROUND: There are reports that suggest conservative treatment when a tumor shows clinically complete response (CR) after preoperative chemoradiotherapy in rectal cancer. The aim of this study is to investigate the association between endoscopic complete response (E-CR) and pathologic CR (pCR) and to determine the sensitivity and specificity of E-CR and its clinical utility after preoperative chemoradiotherapy in rectal cancer. METHODS: We analyzed prospectively collected data of patients with middle and lower rectal cancers who underwent preoperative chemoradiotherapy, between January 2010 and January 2015. RESULTS: Nineteen patients (17.9 %) showed E-CR, and 87 patients showed E-non CR. Twenty-three patients (21.7 %) were confirmed to have pCR. E-CR was closely associated with pCR (p < 0.001). E-CR reflected pCR with an accuracy of 88.7 %, sensitivity of 65.2 %, specificity of 95.2 %, PPV of 78.9 %, NPV of 90.8 %, and a p value of <0.001. CONCLUSIONS: E-CR after preoperative chemoradiotherapy in rectal cancer is significantly associated with pCR. However, a wait and see policy should be performed carefully with current endoscopic prediction for pCR to avoid inadequate treatment in patients who show E-CR after preoperative chemoradiotherapy.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHChemoradiotherapy-
dc.subject.MESHEndoscopy, Gastrointestinal-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoadjuvant Therapy-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRectal Neoplasms-
dc.subject.MESHRemission Induction-
dc.titleClinical Significance of the Endoscopic Finding in Predicting Complete Tumor Response to Preoperative Chemoradiation Therapy in Rectal Cancer-
dc.typeArticle-
dc.identifier.pmid27464916-
dc.contributor.affiliatedAuthor임, 선교-
dc.contributor.affiliatedAuthor김, 영배-
dc.contributor.affiliatedAuthor오, 승엽-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00268-016-3661-4-
dc.citation.titleWorld journal of surgery-
dc.citation.volume40-
dc.citation.number12-
dc.citation.date2016-
dc.citation.startPage3029-
dc.citation.endPage3034-
dc.identifier.bibliographicCitationWorld journal of surgery, 40(12). : 3029-3034, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1432-2323-
dc.relation.journalidJ003642313-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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