Cited 0 times in Scipus Cited Count

Comparing the Effectiveness and Safety of the Addition of and Switching to Aripiprazole for Resolving Antipsychotic-Induced Hyperprolactinemia: A Multicenter, Open-Label, Prospective Study

DC Field Value Language
dc.contributor.authorYoon, HW-
dc.contributor.authorLee, JS-
dc.contributor.authorPark, SJ-
dc.contributor.authorLee, SK-
dc.contributor.authorChoi, WJ-
dc.contributor.authorKim, TY-
dc.contributor.authorHong, CH-
dc.contributor.authorSeok, JH-
dc.contributor.authorPark, IH-
dc.contributor.authorSon, SJ-
dc.contributor.authorRoh, D-
dc.contributor.authorKim, BR-
dc.contributor.authorLee, BO-
dc.date.accessioned2018-05-04T00:24:11Z-
dc.date.available2018-05-04T00:24:11Z-
dc.date.issued2016-
dc.identifier.issn0362-5664-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/14821-
dc.description.abstractOBJECTIVES: Hyperprolactinemia is an important but often overlooked adverse effect of antipsychotics. Several studies have shown that switching to or adding aripiprazole normalizes antipsychotic-induced hyperprolactinemia. However, no study has directly compared the effectiveness and safety of the 2 strategies. METHODS: A total of 52 patients with antipsychotic-induced hyperprolactinemia were recruited. Aripiprazole was administered to patients with mild hyperprolactinemia (serum prolactin level < 50 ng/mL). Patients with severe hyperprolactinemia (serum prolactin level > 50 ng/mL) were randomized to an aripiprazole-addition group (adding aripiprazole to previous antipsychotics) or a switching group (switching previous antipsychotics to aripiprazole). Serum prolactin level, menstrual disturbances, sexual dysfunction, psychopathologies, and quality of life were measured at weeks 0, 1, 2, 4, 6, and 8. RESULTS: Both the addition and switching groups showed significantly reduced serum prolactin level and menstrual disturbances and improved sexual dysfunction. In patients with severe hyperprolactinemia, the numbers of patients with hyperprolactinemia and menstrual disturbance in the switching group were significantly lower than those in the addition group at week 8. CONCLUSIONS: Both the addition and switching strategies were effective in resolving antipsychotic-induced hyperprolactinemia and hyperprolactinemia-related adverse events, including menstrual disturbances and sexual dysfunction. In addition, these findings suggest that switching to aripiprazole may be more effective than addition of aripiprazole for normalizing hyperprolactinemia and improving hyperprolactinemia-related adverse events in patients with schizophrenia.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAntipsychotic Agents-
dc.subject.MESHAripiprazole-
dc.subject.MESHDrug Synergism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyperprolactinemia-
dc.subject.MESHMale-
dc.subject.MESHMenstruation Disturbances-
dc.subject.MESHMental Disorders-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProlactin-
dc.subject.MESHProspective Studies-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSexual Dysfunction, Physiological-
dc.subject.MESHTime Factors-
dc.subject.MESHYoung Adult-
dc.titleComparing the Effectiveness and Safety of the Addition of and Switching to Aripiprazole for Resolving Antipsychotic-Induced Hyperprolactinemia: A Multicenter, Open-Label, Prospective Study-
dc.typeArticle-
dc.identifier.pmid27438182-
dc.contributor.affiliatedAuthor홍, 창형-
dc.contributor.affiliatedAuthor손, 상준-
dc.type.localJournal Papers-
dc.identifier.doi10.1097/WNF.0000000000000175-
dc.citation.titleClinical neuropharmacology-
dc.citation.volume39-
dc.citation.number6-
dc.citation.date2016-
dc.citation.startPage288-
dc.citation.endPage294-
dc.identifier.bibliographicCitationClinical neuropharmacology, 39(6). : 288-294, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1537-162X-
dc.relation.journalidJ003625664-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse