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Comparison of remifentanil EC50 for facilitating i-gel and laryngeal mask airway insertion with propofol anesthesia

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dc.contributor.authorChoi, JB-
dc.contributor.authorKwak, HJ-
dc.contributor.authorLee, KC-
dc.contributor.authorLee, SR-
dc.contributor.authorLee, SY-
dc.contributor.authorKim, JY-
dc.date.accessioned2018-05-04T00:24:17Z-
dc.date.available2018-05-04T00:24:17Z-
dc.date.issued2016-
dc.identifier.issn0913-8668-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/14832-
dc.description.abstractOBJECTIVE: Each supraglottic airway requires different anesthetic depth because it has a specific structure and different compressive force in the oropharyngeal cavity. We designed the study to compare the effect-site concentration (Ce) of remifentanil in 50 % of patients (EC50) for successful insertion of the i-gel second-generation supraglottic airway device with that for laryngeal mask airway (LMA) insertion during target-controlled infusion (TCI) of propofol. METHODS: Forty-one female patients were randomized to the i-gel group (n = 20) or the LMA group (n = 21). Anesthesia was induced with propofol Ce of 5 mug/ml and the predetermined remifentanil Ce, and the i-gel or LMA was inserted 5 min later. The remifentanil Ce was estimated by modified Dixon's up-and-down method (initial concentration: 3.0 ng/ml, step size: 0.5 ng/ml). The patient's response to device insertion was classified as either "success (no movement)" or "failure (movement)". RESULTS: Using the Dixon's up-and-down method, EC50 of remifentanil Ce for the i-gel (1.58 +/- 0.41 ng/ml) was significantly lower than that for LMA (2.25 +/- 0.55 ng/ml) (p = 0.038). Using isotonic regression, EC50 (83 % CI) of remifentanil in the i-gel group [1.50 (1.37-1.80) ng/ml] was statistically lower than that in the LMA group [2.00 (1.82-2.34) ng/ml]. EC95 (95 % CI) of remifentanil in the i-gel group [2.38 (1.48-2.50) ng/ml] was statistically lower than that in the LMA group [3.35 (2.58-3.48) ng/ml]. CONCLUSIONS: We found that EC50 of remifentanil Ce for i-gel insertion (1.58 ng/ml) was significantly lower than that for LMA insertion (2.25 ng/ml) in female patients during propofol TCI without neuromuscular blockade.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAnesthesia-
dc.subject.MESHAnesthetics, Intravenous-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLaryngeal Masks-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuromuscular Blockade-
dc.subject.MESHPiperidines-
dc.subject.MESHPressure-
dc.subject.MESHPropofol-
dc.titleComparison of remifentanil EC50 for facilitating i-gel and laryngeal mask airway insertion with propofol anesthesia-
dc.typeArticle-
dc.identifier.pmid26758073-
dc.contributor.affiliatedAuthor이, 숙영-
dc.contributor.affiliatedAuthor김, 종엽-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00540-015-2133-6-
dc.citation.titleJournal of anesthesia-
dc.citation.volume30-
dc.citation.number3-
dc.citation.date2016-
dc.citation.startPage377-
dc.citation.endPage383-
dc.identifier.bibliographicCitationJournal of anesthesia, 30(3). : 377-383, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1438-8359-
dc.relation.journalidJ009138668-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
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