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Hepatic Venous Pressure Gradient Predicts Long-Term Mortality in Patients with Decompensated Cirrhosis

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dc.contributor.authorKim, TY-
dc.contributor.authorLee, JG-
dc.contributor.authorSohn, JH-
dc.contributor.authorKim, JY-
dc.contributor.authorKim, SM-
dc.contributor.authorKim, J-
dc.contributor.authorJeong, WK-
dc.date.accessioned2018-05-04T00:25:01Z-
dc.date.available2018-05-04T00:25:01Z-
dc.date.issued2016-
dc.identifier.issn0513-5796-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/14947-
dc.description.abstractPURPOSE: The present study aimed to investigate the role of hepatic venous pressure gradient (HVPG) for prediction of long-term mortality in patients with decompensated cirrhosis. MATERIALS AND METHODS: Clinical data from 97 non-critically-ill cirrhotic patients with HVPG measurements were retrospectively and consecutively collected between 2009 and 2012. Patients were classified according to clinical stages and presence of ascites. The prognostic accuracy of HVPG for death, survival curves, and hazard ratios were analyzed. RESULTS: During a median follow-up of 24 (interquartile range, 13-36) months, 22 patients (22.7%) died. The area under the receiver operating characteristics curves of HVPG for predicting 1-year, 2-year, and overall mortality were 0.801, 0.737, and 0.687, respectively (all p<0.01). The best cut-off value of HVPG for predicting long-term overall mortality in all patients was 17 mm Hg. The mortality rates at 1 and 2 years were 8.9% and 19.2%, respectively: 1.9% and 11.9% with HVPG 17 mm Hg, respectively (p=0.015). In the ascites group, the mortality rates at 1 and 2 years were 3.9% and 17.6% with HVPG 17 mm Hg, respectively (p=0.044). Regarding the risk factors for mortality, both HVPG and model for end-stage liver disease were positively related with long-term mortality in all patients. Particularly, for the patients with ascites, both prothrombin time and HVPG were independent risk factors for predicting poor outcomes. CONCLUSION: HVPG is useful for predicting the long-term mortality in patients with decompensated cirrhosis, especially in the presence of ascites.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAscites-
dc.subject.MESHFemale-
dc.subject.MESHHepatic Veins-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLiver Cirrhosis-
dc.subject.MESHLiver Failure-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHROC Curve-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHVenous Pressure-
dc.titleHepatic Venous Pressure Gradient Predicts Long-Term Mortality in Patients with Decompensated Cirrhosis-
dc.typeArticle-
dc.identifier.pmid26632394-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696945/-
dc.contributor.affiliatedAuthor김, 진우-
dc.type.localJournal Papers-
dc.identifier.doi10.3349/ymj.2016.57.1.138-
dc.citation.titleYonsei medical journal-
dc.citation.volume57-
dc.citation.number1-
dc.citation.date2016-
dc.citation.startPage138-
dc.citation.endPage145-
dc.identifier.bibliographicCitationYonsei medical journal, 57(1). : 138-145, 2016-
dc.identifier.eissn1976-2437-
dc.relation.journalidJ005135796-
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Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
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