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Incidence and Morphological Predictors of Intrastent Coronary Thrombus After Drug-Eluting Stent Implantation (from a Multicenter Registry)

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dc.contributor.authorGao, L-
dc.contributor.authorLee, S-
dc.contributor.authorKim, CJ-
dc.contributor.authorMinami, Y-
dc.contributor.authorOng, DS-
dc.contributor.authorSoeda, T-
dc.contributor.authorLowe, H-
dc.contributor.authorChoi, SY-
dc.contributor.authorLerman, A-
dc.contributor.authorLee, J-
dc.contributor.authorLee, H-
dc.contributor.authorUemura, S-
dc.contributor.authorYu, B-
dc.contributor.authorJang, IK-
dc.date.accessioned2018-05-04T00:25:19Z-
dc.date.available2018-05-04T00:25:19Z-
dc.date.issued2016-
dc.identifier.issn0002-9149-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/14984-
dc.description.abstractThe mechanisms responsible for late and very late stent thrombosis remain incompletely understood. This study aimed to evaluate the incidence and morphologic predictors of intrastent thrombus in patients after drug-eluting stent (DES) implantation using optical coherence tomography (OCT). A total of 208 patients with 262 DES who underwent follow-up OCT examination >6 months after DES implantation were included. The detailed vascular morphology including characteristics of neointima was analyzed. Thrombus was identified in 24 patients (11.5%) 11 months after DES implantation. Minimal lumen cross-sectional area was significantly smaller in the thrombus group than in the nonthrombus group (2.9 +/- 1.7 vs 4.6 +/- 2.0 mm(2): p <0.001). No difference was found in the frequency of uncovered or malapposed struts between the 2 groups. Thin-cap fibroatheroma (20.6% vs 0.1%: p <0.001) and heterogeneous neointima (22.2% vs 9.0%: p = 0.001) were more frequently detected in the thrombus group compared to the nonthrombus group. Second-generation DES showed lower incidence of thrombus, uncovered struts, and extrastent lumen compared with first-generation DES. In conclusion, the present OCT study revealed that smaller lumen cross-sectional area and neointimal morphology are important factors associated with intrastent thrombus. Second-generation DES demonstrated improved arterial healing and a lower incidence of intrastent thrombus compared with first-generation DES.-
dc.language.isoen-
dc.subject.MESHAcute Coronary Syndrome-
dc.subject.MESHAngioscopy-
dc.subject.MESHAustralia-
dc.subject.MESHChina-
dc.subject.MESHCoronary Thrombosis-
dc.subject.MESHCoronary Vessels-
dc.subject.MESHDrug-Eluting Stents-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGraft Occlusion, Vascular-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHJapan-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRegistries-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTomography, Optical Coherence-
dc.subject.MESHUnited States-
dc.titleIncidence and Morphological Predictors of Intrastent Coronary Thrombus After Drug-Eluting Stent Implantation (from a Multicenter Registry)-
dc.typeArticle-
dc.identifier.pmid26705880-
dc.contributor.affiliatedAuthor최, 소연-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.amjcard.2015.10.055-
dc.citation.titleThe American journal of cardiology-
dc.citation.volume117-
dc.citation.number3-
dc.citation.date2016-
dc.citation.startPage369-
dc.citation.endPage375-
dc.identifier.bibliographicCitationThe American journal of cardiology, 117(3). : 369-375, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1879-1913-
dc.relation.journalidJ000029149-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
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