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Involvement of T cells in early evolving segmental vitiligo

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dc.contributor.authorShin, J-
dc.contributor.authorKang, HY-
dc.contributor.authorKim, KH-
dc.contributor.authorPark, CJ-
dc.contributor.authorOh, SH-
dc.contributor.authorLee, SC-
dc.contributor.authorLee, S-
dc.contributor.authorChoi, GS-
dc.contributor.authorHann, SK-
dc.date.accessioned2018-05-04T00:25:24Z-
dc.date.available2018-05-04T00:25:24Z-
dc.date.issued2016-
dc.identifier.issn0307-6938-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15000-
dc.description.abstractRecent studies have suggested an overlapping autoimmune mechanism between segmental vitiligo (SV) and nonsegmental vitiligo (NSV). Although T-cell infiltration is observed in the margins of active lesions in NSV, the histopathological characteristics of the active margin of SV are not well known. To determine if T-cell inflammatory responses are present in the active margin of SV lesions, biopsies were taken from the active margin of a lesion in 12 patients with early or actively spreading SV and compared with a normal control sample (on the symmetrical, opposite site of the same dermatome). The samples were stained for CD4, CD8, CD25 and interferon-gamma. Lymphocytic infiltration was seen in 70% of patients. CD4+ T cells infiltrated the dermis, while CD8+ T cells were present in the epidermis or attached to the basal layer. The increase in the number of CD8+ T cells was significant (P < 0.04), while CD4+ or CD25+ T cells also appeared to be increased in number, but this was not significant. These results suggest that SV also has an autoimmune mechanism in the early evolving stage.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHCD8-Positive T-Lymphocytes-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHEpidermis-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents-
dc.subject.MESHInterferon-gamma-
dc.subject.MESHMale-
dc.subject.MESHMelanocytes-
dc.subject.MESHMiddle Aged-
dc.subject.MESHSkin-
dc.subject.MESHT-Lymphocytes-
dc.subject.MESHVitiligo-
dc.subject.MESHYoung Adult-
dc.titleInvolvement of T cells in early evolving segmental vitiligo-
dc.typeArticle-
dc.identifier.pmid27334675-
dc.contributor.affiliatedAuthor강, 희영-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/ced.12852-
dc.citation.titleClinical and experimental dermatology-
dc.citation.volume41-
dc.citation.number6-
dc.citation.date2016-
dc.citation.startPage671-
dc.citation.endPage674-
dc.identifier.bibliographicCitationClinical and experimental dermatology, 41(6). : 671-674, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1365-2230-
dc.relation.journalidJ003076938-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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