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Minimum absolute lymphocyte count during radiotherapy as a new prognostic factor for nasopharyngeal cancer

Authors
Cho, O  | Oh, YT  | Chun, M  | Noh, OK  | Hoe, JS  | Kim, H
Citation
Head & neck, 38 Suppl 1. : E1061-E1067, 2016
Journal Title
Head & neck
ISSN
1043-30741097-0347
Abstract
BACKGROUND: The purpose of this study was to investigate whether the minimum absolute lymphocyte count (ALC) during radiotherapy (RT) could predict clinical outcome in patients with nasopharyngeal cancer (NPC). METHODS: We analyzed 70 patients with NPC including 63 patients treated with chemoradiotherapy and used multivariate analysis to determine whether minimum ALC affected clinical outcome. RESULTS: Patients were grouped by minimum ALC, with a cutoff of 245 cells/muL. Five-year disease-specific survival (DSS) and progression-free survival (PFS) for patients with minimum ALC >/=245 versus minimum ALC <245 were 88.1% versus 60.8% (p = .004) and 71.2% versus 35.2% (p = .004). All 10 patients with minimum ALC <120 experienced disease progression. Four of 6 patients (67%) with ALC <120 who died experienced disease progression within 6 months. CONCLUSION: Minimum ALC may predict poor 5-year DSS and should be evaluated by prospective studies. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: E1061-E1067, 2016.
MeSH

DOI
10.1002/hed.24158
PMID
26040623
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Ajou Authors
노, 오규  |  오, 영택  |  전, 미선  |  조, 오연  |  허, 재성
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