BROWSE

Cited 0 times in Scipus Cited Count

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

DC Field Value Language
dc.contributor.authorLu, Y-
dc.contributor.authorDay, FR-
dc.contributor.authorGustafsson, S-
dc.contributor.authorBuchkovich, ML-
dc.contributor.authorNa, J-
dc.contributor.authorBataille, V-
dc.contributor.authorCousminer, DL-
dc.contributor.authorDastani, Z-
dc.contributor.authorDrong, AW-
dc.contributor.authorEsko, T-
dc.contributor.authorEvans, DM-
dc.contributor.authorFalchi, M-
dc.contributor.authorFeitosa, MF-
dc.contributor.authorFerreira, T-
dc.contributor.authorHedman, AK-
dc.contributor.authorHaring, R-
dc.contributor.authorHysi, PG-
dc.contributor.authorIles, MM-
dc.contributor.authorJustice, AE-
dc.contributor.authorKanoni, S-
dc.contributor.authorLagou, V-
dc.contributor.authorLi, R-
dc.contributor.authorLi, X-
dc.contributor.authorLocke, A-
dc.contributor.authorLu, C-
dc.contributor.authorMagi, R-
dc.contributor.authorPerry, JR-
dc.contributor.authorPers, TH-
dc.contributor.authorQi, Q-
dc.contributor.authorSanna, M-
dc.contributor.authorSchmidt, EM-
dc.contributor.authorScott, WR-
dc.contributor.authorShungin, D-
dc.contributor.authorTeumer, A-
dc.contributor.authorVinkhuyzen, AA-
dc.contributor.authorWalker, RW-
dc.contributor.authorWestra, HJ-
dc.contributor.authorZhang, M-
dc.contributor.authorZhang, W-
dc.contributor.authorZhao, JH-
dc.contributor.authorZhu, Z-
dc.contributor.authorAfzal, U-
dc.contributor.authorAhluwalia, TS-
dc.contributor.authorBakker, SJ-
dc.contributor.authorBellis, C-
dc.contributor.authorBonnefond, A-
dc.contributor.authorBorodulin, K-
dc.contributor.authorBuchman, AS-
dc.contributor.authorCederholm, T-
dc.contributor.authorChoh, AC-
dc.contributor.authorChoi, HJ-
dc.contributor.authorCurran, JE-
dc.contributor.authorde Groot, LC-
dc.contributor.authorDe Jager, PL-
dc.contributor.authorDhonukshe-Rutten, RA-
dc.contributor.authorEnneman, AW-
dc.contributor.authorEury, E-
dc.contributor.authorEvans, DS-
dc.contributor.authorForsen, T-
dc.contributor.authorFriedrich, N-
dc.contributor.authorFumeron, F-
dc.contributor.authorGarcia, ME-
dc.contributor.authorGartner, S-
dc.contributor.authorHan, BG-
dc.contributor.authorHavulinna, AS-
dc.contributor.authorHayward, C-
dc.contributor.authorHernandez, D-
dc.contributor.authorHillege, H-
dc.contributor.authorIttermann, T-
dc.contributor.authorKent, JW-
dc.contributor.authorKolcic, I-
dc.contributor.authorLaatikainen, T-
dc.contributor.authorLahti, J-
dc.contributor.authorMateo Leach, I-
dc.contributor.authorLee, CG-
dc.contributor.authorLee, JY-
dc.contributor.authorLiu, T-
dc.contributor.authorLiu, Y-
dc.contributor.authorLobbens, S-
dc.contributor.authorLoh, M-
dc.contributor.authorLyytikainen, LP-
dc.contributor.authorMedina-Gomez, C-
dc.contributor.authorMichaelsson, K-
dc.contributor.authorNalls, MA-
dc.contributor.authorNielson, CM-
dc.contributor.authorOozageer, L-
dc.contributor.authorPascoe, L-
dc.contributor.authorPaternoster, L-
dc.contributor.authorPolasek, O-
dc.contributor.authorRipatti, S-
dc.contributor.authorSarzynski, MA-
dc.contributor.authorShin, CS-
dc.contributor.authorNarancic, NS-
dc.contributor.authorSpira, D-
dc.contributor.authorSrikanth, P-
dc.contributor.authorSteinhagen-Thiessen, E-
dc.contributor.authorSung, YJ-
dc.contributor.authorSwart, KM-
dc.contributor.authorTaittonen, L-
dc.contributor.authorTanaka, T-
dc.contributor.authorTikkanen, E-
dc.contributor.authorvan der Velde, N-
dc.contributor.authorvan Schoor, NM-
dc.contributor.authorVerweij, N-
dc.contributor.authorWright, AF-
dc.contributor.authorYu, L-
dc.contributor.authorZmuda, JM-
dc.contributor.authorEklund, N-
dc.contributor.authorForrester, T-
dc.contributor.authorGrarup, N-
dc.contributor.authorJackson, AU-
dc.contributor.authorKristiansson, K-
dc.contributor.authorKuulasmaa, T-
dc.contributor.authorKuusisto, J-
dc.contributor.authorLichtner, P-
dc.contributor.authorLuan, J-
dc.contributor.authorMahajan, A-
dc.contributor.authorMannisto, S-
dc.contributor.authorPalmer, CD-
dc.contributor.authorRied, JS-
dc.contributor.authorScott, RA-
dc.contributor.authorStancakova, A-
dc.contributor.authorWagner, PJ-
dc.contributor.authorDemirkan, A-
dc.contributor.authorDoring, A-
dc.contributor.authorGudnason, V-
dc.contributor.authorKiel, DP-
dc.contributor.authorKuhnel, B-
dc.contributor.authorMangino, M-
dc.contributor.authorMcKnight, B-
dc.contributor.authorMenni, C-
dc.contributor.authorO'Connell, JR-
dc.contributor.authorOostra, BA-
dc.contributor.authorShuldiner, AR-
dc.contributor.authorSong, K-
dc.contributor.authorVandenput, L-
dc.contributor.authorvan Duijn, CM-
dc.contributor.authorVollenweider, P-
dc.contributor.authorWhite, CC-
dc.contributor.authorBoehnke, M-
dc.contributor.authorBoettcher, Y-
dc.contributor.authorCooper, RS-
dc.contributor.authorForouhi, NG-
dc.contributor.authorGieger, C-
dc.contributor.authorGrallert, H-
dc.contributor.authorHingorani, A-
dc.contributor.authorJorgensen, T-
dc.contributor.authorJousilahti, P-
dc.contributor.authorKivimaki, M-
dc.contributor.authorKumari, M-
dc.contributor.authorLaakso, M-
dc.contributor.authorLangenberg, C-
dc.contributor.authorLinneberg, A-
dc.contributor.authorLuke, A-
dc.contributor.authorMcKenzie, CA-
dc.contributor.authorPalotie, A-
dc.contributor.authorPedersen, O-
dc.contributor.authorPeters, A-
dc.contributor.authorStrauch, K-
dc.contributor.authorTayo, BO-
dc.contributor.authorWareham, NJ-
dc.contributor.authorBennett, DA-
dc.contributor.authorBertram, L-
dc.contributor.authorBlangero, J-
dc.contributor.authorBluher, M-
dc.contributor.authorBouchard, C-
dc.contributor.authorCampbell, H-
dc.contributor.authorCho, NH-
dc.contributor.authorCummings, SR-
dc.contributor.authorCzerwinski, SA-
dc.contributor.authorDemuth, I-
dc.contributor.authorEckardt, R-
dc.contributor.authorEriksson, JG-
dc.contributor.authorFerrucci, L-
dc.contributor.authorFranco, OH-
dc.contributor.authorFroguel, P-
dc.contributor.authorGansevoort, RT-
dc.contributor.authorHansen, T-
dc.contributor.authorHarris, TB-
dc.contributor.authorHastie, N-
dc.contributor.authorHeliovaara, M-
dc.contributor.authorHofman, A-
dc.contributor.authorJordan, JM-
dc.contributor.authorJula, A-
dc.contributor.authorKahonen, M-
dc.contributor.authorKajantie, E-
dc.contributor.authorKnekt, PB-
dc.contributor.authorKoskinen, S-
dc.contributor.authorKovacs, P-
dc.contributor.authorLehtimaki, T-
dc.contributor.authorLind, L-
dc.contributor.authorLiu, Y-
dc.contributor.authorOrwoll, ES-
dc.contributor.authorOsmond, C-
dc.contributor.authorPerola, M-
dc.contributor.authorPerusse, L-
dc.contributor.authorRaitakari, OT-
dc.contributor.authorRankinen, T-
dc.contributor.authorRao, DC-
dc.contributor.authorRice, TK-
dc.contributor.authorRivadeneira, F-
dc.contributor.authorRudan, I-
dc.contributor.authorSalomaa, V-
dc.contributor.authorSorensen, TI-
dc.contributor.authorStumvoll, M-
dc.contributor.authorTonjes, A-
dc.contributor.authorTowne, B-
dc.contributor.authorTranah, GJ-
dc.contributor.authorTremblay, A-
dc.contributor.authorUitterlinden, AG-
dc.contributor.authorvan der Harst, P-
dc.contributor.authorVartiainen, E-
dc.contributor.authorViikari, JS-
dc.contributor.authorVitart, V-
dc.contributor.authorVohl, MC-
dc.contributor.authorVolzke, H-
dc.contributor.authorWalker, M-
dc.contributor.authorWallaschofski, H-
dc.contributor.authorWild, S-
dc.contributor.authorWilson, JF-
dc.contributor.authorYengo, L-
dc.contributor.authorBishop, DT-
dc.contributor.authorBorecki, IB-
dc.contributor.authorChambers, JC-
dc.contributor.authorCupples, LA-
dc.contributor.authorDehghan, A-
dc.contributor.authorDeloukas, P-
dc.contributor.authorFatemifar, G-
dc.contributor.authorFox, C-
dc.contributor.authorFurey, TS-
dc.contributor.authorFranke, L-
dc.contributor.authorHan, J-
dc.contributor.authorHunter, DJ-
dc.contributor.authorKarjalainen, J-
dc.contributor.authorKarpe, F-
dc.contributor.authorKaplan, RC-
dc.contributor.authorKooner, JS-
dc.contributor.authorMcCarthy, MI-
dc.contributor.authorMurabito, JM-
dc.contributor.authorMorris, AP-
dc.contributor.authorBishop, JA-
dc.contributor.authorNorth, KE-
dc.contributor.authorOhlsson, C-
dc.contributor.authorOng, KK-
dc.contributor.authorProkopenko, I-
dc.contributor.authorRichards, JB-
dc.contributor.authorSchadt, EE-
dc.contributor.authorSpector, TD-
dc.contributor.authorWiden, E-
dc.contributor.authorWiller,-
dc.date.accessioned2018-05-04T00:25:47Z-
dc.date.available2018-05-04T00:25:47Z-
dc.date.issued2016-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15050-
dc.description.abstractTo increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.-
dc.language.isoen-
dc.subject.MESHAdiposity-
dc.subject.MESHAnimals-
dc.subject.MESHDrosophila melanogaster-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHGene Knockdown Techniques-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHGenome-Wide Association Study-
dc.subject.MESHHeart Diseases-
dc.subject.MESHHumans-
dc.subject.MESHQuantitative Trait Loci-
dc.titleNew loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk-
dc.typeArticle-
dc.identifier.pmid26833246-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740398/-
dc.contributor.affiliatedAuthor조, 남한-
dc.type.localJournal Papers-
dc.identifier.doi10.1038/ncomms10495-
dc.citation.titleNature communications-
dc.citation.volume7-
dc.citation.date2016-
dc.citation.startPage10495-
dc.citation.endPage10495-
dc.identifier.bibliographicCitationNature communications, 7. : 10495-10495, 2016-
dc.identifier.eissn2041-1723-
dc.relation.journalidJ020411723-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
Files in This Item:
26833246.pdfDownload
Show simple item record

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

  • License
    sherpa_romeo
    sherpa_juliet

OAK

Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312
Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved.
AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.

Browse

Guide 아주대학교 의학문헌정보센터