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Selection of a mobilization regimen for multiple myeloma based on the response to induction therapy: granulocyte-colony stimulating factor (G-CSF) alone versus high-dose cyclophosphamide plus G-CSF

Authors
Jang, JE | Cheong, JW | Kim, SJ | Cho, H | Suh, C | Lee, H | Eom, HS | Yhim, HY | Lee, WS | Min, CK | Lee, JH | Park, JS  | Kim, JS
Citation
Leukemia & lymphoma, 57(6). : 1389-1397, 2016
Journal Title
Leukemia & lymphoma
ISSN
1042-81941029-2403
Abstract
To evaluate the feasibility of selecting a mobilization regimen based on the response to induction therapy, we retrospectively analyzed 179 multiple myeloma patients who underwent stem cell mobilization. In comparison with patients who achieved at least a very good partial response (VGPR) to induction therapy and received granulocyte-colony stimulating factor (G-CSF) alone and patients who did not achieve a VGPR and received cyclophosphamide (CY) + G-CSF, treatment-related toxicity was greater and neutrophil engraftment was slower in the CY than the G-CSF group. The rate of requisite mobilization (>/= 2.0 x 10(6)/kg) was similar in both groups. Overall and progression-free survival was not different between patients in the G-CSF group and patients who achieved at least VGPR and received CY + G-CSF. In conclusion, response-adapted selection of a mobilization regimen is appropriate. G-CSF alone should be the preferred treatment for patients who achieved at least a VGPR to induction therapy.
MeSH

DOI
10.3109/10428194.2015.1102240
PMID
26428939
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Ajou Authors
박, 준성
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