Cited 0 times in Scipus Cited Count

Significance of Time-Zero Biopsy for Graft Renal Function After Deceased Donor Kidney Transplantation

Lee, AL | Huh, KH | Lee, SH  | Lee, JJ | Joo, DJ | Jeong, HJ | Kim, MS | Kim, SI | Kim, YS
Transplantation proceedings, 48(8). : 2656-2662, 2016
Journal Title
Transplantation proceedings
BACKGROUND: Donor organ quality from deceased donors affects graft survival after kidney transplantation. This study was performed to identify clinico-histological factors that affect early graft outcome, using time-zero biopsies of deceased donors. METHODS: Between December 2006 and July 2011, 135 recipients of deceased donor kidneys were included, and data concerning donor and recipient-related clinical characteristics and histological findings of time-zero biopsies categorized by use of the Banff 07 scoring system were included in the analysis. Mean donor age was 44.3 +/- 12.3 years. Mean terminal serum creatinine level and cold ischemic time were 1.50 +/- 0.96 mg/dL and 349 +/- 166 minutes. Mean follow-up time after transplantation was 37 +/- 16 months, and all recipients were followed for at least 1 year. RESULTS: Global glomerulosclerosis (38.5%), tubular atrophy (37.8%), arteriolar hyaline thickening (25.9%), interstitial fibrosis (23%), vascular fibrous intimal thickening (21.5%), and interstitial inflammation (20%) were the major pathologic findings of time-zero biopsies. The majority of pathologic scores were of mild degree. Among histological findings, arteriolar hyaline thickening and interstitial fibrosis were only significantly associated with early post-transplant renal function in multivariate analyses. CONCLUSIONS: Considerations of clinico-histological findings were found to be valuable for predicting early graft outcome after deceased donor kidney transplantation.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Ajou Authors
이, 수형
Files in This Item:
There are no files associated with this item.


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.