Cited 0 times in Scipus Cited Count

The prognostic value of total lesion glycolysis via 18F-fluorodeoxyglucose PET-CT in surgically treated esophageal squamous cell carcinoma

DC Field Value Language
dc.contributor.authorPark, SY-
dc.contributor.authorLee, SJ-
dc.contributor.authorYoon, JK-
dc.date.accessioned2018-05-04T00:26:48Z-
dc.date.available2018-05-04T00:26:48Z-
dc.date.issued2016-
dc.identifier.issn0914-7187-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15186-
dc.description.abstractOBJECTIVE: In addition to staging, the identification of prognostic factors is important for predicting survival in patients with esophageal cancer after esophagectomy. The present study was performed to document the prognostic role of total lesion glycolysis (TLG) in postoperative patients. METHODS: We retrospectively reviewed the records of 50 patients with esophageal squamous cell carcinoma who underwent surgical resection and complete lymph node dissection after positron emission tomography-computed tomography (PET-CT). A volume of interest was drawn on the primary lesion and suspected metastatic lymph nodes, and the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), TLG of the primary lesion (TLGp), and whole-body TLG (TLGwb) were measured using an SUV cutoff of 2.5. RESULTS: The study population included 50 patients with a mean age of 63.14 +/- 8.18 years: 12 (24%) were reported as stage I, 13 (26%) as stage II, and 25 (50%) as stage III. The median follow-up period was 20.46 months, and recurrences occurred in 17 patients. The mean SUVmax, MTV, TLGp, and TLGwb were 11.11 +/- 6.40, 20.47 +/- 22.88, 122.54 +/- 180.98, and 129.37 +/- 193.66, respectively. On the multivariate analysis, TLGp was a risk factor for disease-free survival (DFS) [hazard ratio (HR) = 1.002, p = 0.026], and TLGwb was a risk factor for DFS (HR = 1.002, p = 0.021) and overall survival (OS) (HR = 1.002, p = 0.044). The 3-year OS rates were 66.1% in patients with low TLGwb (41.45: p = 0.004). The concordance index of the TLGwb was 0.752 (95% CI 0.659-0.845). CONCLUSION: TLGwb is a significant prognostic factor for OS and DFS in patients with surgically treated esophageal squamous cell carcinoma.-
dc.language.isoen-
dc.subject.MESHCarcinoma, Squamous Cell-
dc.subject.MESHEsophageal Neoplasms-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHGlycolysis-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultimodal Imaging-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTomography, X-Ray Computed-
dc.titleThe prognostic value of total lesion glycolysis via 18F-fluorodeoxyglucose PET-CT in surgically treated esophageal squamous cell carcinoma-
dc.typeArticle-
dc.identifier.pmid26497543-
dc.contributor.affiliatedAuthor박, 성용-
dc.contributor.affiliatedAuthor이, 수진-
dc.contributor.affiliatedAuthor윤, 준기-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s12149-015-1034-y-
dc.citation.titleAnnals of nuclear medicine-
dc.citation.volume30-
dc.citation.number1-
dc.citation.date2016-
dc.citation.startPage81-
dc.citation.endPage88-
dc.identifier.bibliographicCitationAnnals of nuclear medicine, 30(1). : 81-88, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1864-6433-
dc.relation.journalidJ009147187-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Thoracic & Cardiovascular Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse