Cited 0 times in Scipus Cited Count

Trabecular Bone Score (TBS) and TBS-Adjusted Fracture Risk Assessment Tool are Potential Supplementary Tools for the Discrimination of Morphometric Vertebral Fractures in Postmenopausal Women With Type 2 Diabetes

Authors
Choi, YJ  | Ock, SY | Chung, YS
Citation
Journal of clinical densitometry, 19(4). : 507-514, 2016
Journal Title
Journal of clinical densitometry
ISSN
1094-6950
Abstract
Type 2 diabetes mellitus (T2DM) is associated with fracture risk but, paradoxically, greater bone mineral density (BMD). The trabecular bone score (TBS) has been proposed as an index of bone microarchitecture associated with bone quality. This study compared the performance of TBS, BMD, and original and TBS-adjusted Fracture Risk Assessment Tool (FRAX(R)) scores in the discrimination of vertebral fractures (VFs) in T2DM patients. This retrospective study enrolled 169 Korean postmenopausal women with T2DM. Lateral plain radiographs of the thoracolumbar spine were taken. Lumbar spine and femur neck BMDs were obtained using dual-energy X-ray absorptiometry (DXA). TBS was obtained using the TBS iNsight software program (Med-Imaps, Pessac, France) with BMD DXA images (L1-L4). VFs were diagnosed when at least 1 of the 3 height measurements was decreased by >25% compared to the nearest uncompressed vertebral body. Among the subjects, 34 women (20.1%) had VFs. Significantly lower TBS (p = 0.008) and higher TBS-adjusted FRAX scores were shown (p = 0.019) in the group with VFs compared to the group without VFs. In contrast, there were no significant differences in BMD and original FRAX scores between the 2 groups. Odds ratios (ORs) per standard deviation decrease in BMD or TBS and per standard deviation increase in the FRAX score were estimated with adjustment for age. TBS (OR = 1.8, 95% confidence interval [CI]: 1.1-2.7, p = 0.011) and TBS-adjusted FRAX score (OR = 2.0, 95% confidence interval: 1.1-3.5, p = 0.020) showed statistically significant ORs but the others did not. TBS and TBS-adjusted FRAX could be supplementary tools to discriminate osteoporotic fractures in T2DM.
MeSH

DOI
10.1016/j.jocd.2016.04.001
PMID
27130256
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Ajou Authors
정, 윤석  |  최, 용준
Files in This Item:
There are no files associated with this item.
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse