143 522

Cited 0 times in

Treatment outcomes in patients with FIGO stage IB-IIA cervical cancer and a focally disrupted cervical stromal ring on magnetic resonance imaging: A propensity score matching study

DC Field Value Language
dc.contributor.authorKong, TW-
dc.contributor.authorLee, JD-
dc.contributor.authorSon, JH-
dc.contributor.authorPaek, J-
dc.contributor.authorChun, M-
dc.contributor.authorChang, SJ-
dc.contributor.authorRyu, HS-
dc.date.accessioned2018-05-04T00:26:59Z-
dc.date.available2018-05-04T00:26:59Z-
dc.date.issued2016-
dc.identifier.issn0090-8258-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15209-
dc.description.abstractOBJECTIVE: The aim of this study was to compare treatment outcomes of primary concurrent chemoradiation therapy (CCRT) versus radical hysterectomy (RH) followed by adjuvant RT or CCRT in patients with FIGO stage IB-IIA cervical cancer with focal disruption of the cervical stromal ring on magnetic resonance imaging (MRI). METHODS: We retrospectively analyzed the clinicopathological data of 156 patients with FIGO stage IB-IIA cervical cancer showing a focal disruption of the stromal ring on MRI between March 2000 and March 2015. Treatment outcomes were compared between the RT-based (n=54) group and RH-based group (n=54) after propensity score matching of each of the patients using a logistic regression model, including age, tumor size on MRI, pelvic lymph node enlargement on MRI, and histology. RESULTS: Five-year disease-free survival rate was 83.1% for the RT-based group and 77.4% for the RH-based group (p=0.228). Five-year disease-specific survival rate was 84.3% for the RT-based group and 83.5% for the RH-based group (p=0.434). Incidence rates of late grade 3 genitourinary adverse reactions (14.8% vs. 0.0%, p=0.006) were significantly higher in the RH-based group than those in the RT-based group. CONCLUSIONS: Primary CCRT might be the preferred treatment for FIGO stage IB-IIA cervical cancer patients with focal disruption of cervical stromal ring on MRI given that no difference in patient's survival was found, but higher incidence of treatment-related complications was observed in the RH-based group. Also, primary radical surgery should be done more cautiously in these patients.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCervix Uteri/pathology-
dc.subject.MESHChemoradiotherapy-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHysterectomy-
dc.subject.MESHMagnetic Resonance Imaging/methods-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPropensity Score-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUterine Cervical Neoplasms/diagnostic imaging-
dc.subject.MESHUterine Cervical Neoplasms/mortality-
dc.subject.MESHUterine Cervical Neoplasms/pathology-
dc.subject.MESHUterine Cervical Neoplasms/therapy-
dc.titleTreatment outcomes in patients with FIGO stage IB-IIA cervical cancer and a focally disrupted cervical stromal ring on magnetic resonance imaging: A propensity score matching study-
dc.typeArticle-
dc.identifier.pmid27423377-
dc.contributor.affiliatedAuthor공, 태욱-
dc.contributor.affiliatedAuthor손, 주혁-
dc.contributor.affiliatedAuthor백, 지흠-
dc.contributor.affiliatedAuthor전, 미선-
dc.contributor.affiliatedAuthor장, 석준-
dc.contributor.affiliatedAuthor유, 희석-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.ygyno.2016.07.102-
dc.citation.titleGynecologic oncology-
dc.citation.volume143-
dc.citation.number1-
dc.citation.date2016-
dc.citation.startPage77-
dc.citation.endPage82-
dc.identifier.bibliographicCitationGynecologic oncology, 143(1). : 77-82, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1095-6859-
dc.relation.journalidJ000908258-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Files in This Item:
27423377.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse