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Which Gene is a Dominant Predictor of Response during FOLFOX Chemotherapy for the Treatment of Metastatic Colorectal Cancer, MTHFR or XRCC1 Gene?
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 김, 주형 | - |
| dc.date.accessioned | 2011-03-03T01:55:02Z | - |
| dc.date.available | 2011-03-03T01:55:02Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/1521 | - |
| dc.description.tableofcontents | "국문요약 ------------------------------------------- i
차례 ----------------------------------------------- iv 그림 차례 ------------------------------------------- v 표 차례---------------------------------------------- vi I. 서론 ------------------------------------------ 1 II. 연구대상 및 방법------------------------------ 4 A. 연구대상 -------------------------------- 4 B. 항암화학요법 방법 및 치료효과의 판정 ----- 4 C. 유전자 다형성 분석 ----------------------- 6 1. DNA preparation and amplification MTHFR and XRCC1------------------- 6 2. Nucleotide sequencing---------------- 7 3. Fluorescence-based direct sequencing.-7 D. 통계학적 분석 --------------------------- 11 III. 결과 ----------------------------------------- 12 A. 대상 환자의 특성--------------------------12 B. 유전자 변이 양상------------------------- 14 C. 항암화학요법에 대한 반응정도------------- 17 D. 유전자 변이양상과 항암화학요법 반응 정도간의 상관관계--------------------------------- 18 IV. 고찰 ---------------------------------------- 22 V. 결론 ---------------------------------------- 28 참고문헌 -------------------------------------------- 29 ABSTRACT------------------------------------------ 34 " | - |
| dc.language.iso | ko | - |
| dc.title | Which Gene is a Dominant Predictor of Response during FOLFOX Chemotherapy for the Treatment of Metastatic Colorectal Cancer, MTHFR or XRCC1 Gene? | - |
| dc.title.alternative | 다제 병합요법이 시행된 전이성 대장암 환자에서 XRCC1 유전자 및 MTHFR 유전자 변이와 약물반응과의 관계 | - |
| dc.type | Thesis | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000000901 | - |
| dc.subject.keyword | 대장암 | - |
| dc.subject.keyword | 유전자변이 | - |
| dc.subject.keyword | 예후인자 | - |
| dc.subject.keyword | X-ray cross-complementing1 유전자 | - |
| dc.subject.keyword | Methylenetetrahydrofolate reductase 유전자 | - |
| dc.description.degree | Doctor | - |
| dc.contributor.department | 대학원 의학과 | - |
| dc.contributor.affiliatedAuthor | 김, 주형 | - |
| dc.date.awarded | 2006 | - |
| dc.type.local | Theses | - |
| dc.citation.date | 2006 | - |
| dc.embargo.liftdate | 9999-12-31 | - |
| dc.embargo.terms | 9999-12-31 | - |
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