Cited 0 times in Scipus Cited Count

Dieckol, an edible seaweed polyphenol, retards rotenone-induced neurotoxicity and α-synuclein aggregation in human dopaminergic neuronal cells

DC Field Value Language
dc.contributor.authorCha, SH-
dc.contributor.authorHeo, SJ-
dc.contributor.authorJeon, YJ-
dc.contributor.authorPark, SM-
dc.date.accessioned2018-05-14T16:30:07Z-
dc.date.available2018-05-14T16:30:07Z-
dc.date.issued2016-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15278-
dc.description.abstractDopaminergic neurons are particularly vulnerable to oxidative stress, which may initiate a cascade of intracellular toxic events that lead to protein aggregation and subsequent cell death, causing Parkinson's disease. Here, we investigate the neuroprotective effect of dieckol, which is a polyphenol isolated from an edible seaweed, Ecklonia cava, on rotenone-induced oxidative stress in SH-SY5Y cells, a human dopaminergic neuronal cell line. Dieckol was found to reduce intracellular reactive oxygen species (ROS) and cytochrome C release induced by treatment with rotenone. Consequently, dieckol reduced rotenone-induced cell death, and retarded rotenone-induced α-synuclein aggregation in α-synuclein-overexpressing SH-SY5Y cells. These results clearly indicate that dieckol possesses prominent antioxidant activity in dopaminergic neuronal cells preventing α-synuclein aggregation. Therefore, it could be a potential therapeutic agent for the prevention of neurodegenerative diseases such as Parkinson's disease.-
dc.language.isoen-
dc.titleDieckol, an edible seaweed polyphenol, retards rotenone-induced neurotoxicity and α-synuclein aggregation in human dopaminergic neuronal cells-
dc.typeArticle-
dc.contributor.affiliatedAuthor차, 선희-
dc.contributor.affiliatedAuthor박, 상면-
dc.type.localJournal Papers-
dc.identifier.doi10.1039/c6ra21697h-
dc.citation.titleRSC advances-
dc.citation.volume6-
dc.citation.number111-
dc.citation.date2016-
dc.citation.startPage110040-
dc.citation.endPage110046-
dc.identifier.bibliographicCitationRSC advances, 6(111). : 110040-110046, 2016-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn2046-2069-
dc.relation.journalidJ020462069-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse