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Chitosan as an Immunomodulating Adjuvant on T-Cells and Antigen-Presenting Cells in Herpes Simplex Virus Type 1 Infection

Authors
Choi, B | Jo, DH | Anower, AK | Islam, SM | Sohn, S
Citation
Mediators of inflammation, 2016. : 4374375-4374375, 2016
Journal Title
Mediators of inflammation
ISSN
0962-93511466-1861
Abstract
Herpes disease caused by herpes simplex virus type 1 (HSV-1) is an intractable condition. It is a major concern in public health. Our purpose of this study was to verify the function of chitosan as an adjuvant for immune regulation specifically under herpes simplex virus type 1 (HSV-1) infection. Ahead of HSV infection, chitosan, heat inactivated green fluorescent protein expressing HSV (G-HSV), and a combination of chitosan and G-HSV were used to pretreat ICR mice followed by HSV-1 infection. Using flow cytometric analysis, the frequencies of T-cells, monocytes, dendritic cells (DCs), and natural killer (NK) cells were analyzed by surface expression of CD4(+), CD8(+), CD14(+), CD11c(+), NK1.1(+), and DX5(+) cells. In HSV infected mice, chitosan treatment significantly increased the frequencies of CD4(+) T-cells (33.6 +/- 5.78%) compared to those in the control group (24.02 +/- 12.47%, p = 0.05). The frequencies of DC and NK cells were also significantly different between chitosan treated mice and control mice. In addition, anti-HSV IgG antibody was downregulated in chitosan treated mice. These results suggest that chitosan is a potential modulator or immune stimulator as an adjuvant in HSV-1 infected mice.
MeSH

DOI
10.1155/2016/4374375
PMID
28096567
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Ajou Authors
손, 성향
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