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Metformin induced acute pancreatitis and lactic acidosis in a patient on hemodialysis.

Other Title
혈액투석 환자에서 메트포르민 복용으로 발생한 급성췌장염과 젖산산증
Lee, YK  | Lim, K  | Hwang, SH | Ahn, YH | Shin, GT  | Kim, H  | Park, IW
Yeungnam University journal of medicine, 33(1). : 33-36, 2016
Journal Title
Yeungnam University journal of medicine
Metformin, commonly prescribed for type 2 diabetes, is considered safe with minimal side-effect. Acute pancreatitis is rare but potentially fatal adverse side-effect of metformin. We report a patient on hemodialysis with metformin-related acute pancreatitis and lactic acidosis. A 62-year-old woman with diabetic nephropathy and hypertension presented with nausea and vomiting for a few weeks, followed by epigastric pain. At home, the therapy of 500 mg/day metformin and 50 mg/day sitagliptin was continued, despite symptoms. Laboratory investigations showed metabolic acidosis with high levels of lactate, amylase at 520 U/L (range, 30-110 U/L), and lipase at 1,250 U/L (range, 23-300 U/L). Acute pancreatitis was confirmed by computed tomography. No recognized cause of acute pancreatitis was identified. Metformin was discontinued. Treatment with insulin and intravenous fluids resulted in normalized amylase, lipase, and lactate. When she was re-exposed to sitagliptin, no symptoms were reported.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Nephrology
Ajou Authors
김, 흥수  |  박, 인휘  |  신, 규태  |  이, 연경  |  임, 기현
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