147 289

Cited 0 times in

The fate of implanted autologous chondrocytes in regenerated articular cartilage.

Min, BH; Woo, JI; Kim, WH; Kweon, OK; Triffitt, JT; Choi, BH; Park, SR
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 221(5):461-465, 2007
Journal Title
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Autologous chondrocyte implantation (ACI) is used to treat some articular cartilage defects. However, the fate of the cultured chondrocytes after in-vivo transplantation and their role in cartilage regeneration remains unclear. To monitor the survival and fate of such cells in vivo, the chondrocytes were labelled with a lipophilic dye and the resultant regenerated tissue in dogs examined. It was found that, 4 weeks after implantation, the osteochondral defects were filled with regenerative tissue that resembled hyaline cartilage. Fluorescence microscopy of frozen sections of the regenerated tissue revealed that the majority of cells were derived from the DiI-labelled implanted chondrocytes. From these results, it was concluded that a large population of implanted autologous chondrocytes can survive at least 4 weeks after implantation and play a direct role in cartilage regeneration. However, it remains unknown whether other cells, such as periosteal cells or bone marrow stromal stem cells, are involved in the regeneration of cartilage after ACI.
MeSH terms
AnimalsCartilage, Articular/injuries*Cartilage, Articular/pathologyCartilage, Articular/surgery*Cell SurvivalCells, CulturedChondrocytes/pathology*Chondrocytes/transplantation*DogsFractures, Cartilage/pathology*Fractures, Cartilage/surgery*Guided Tissue Regeneration/methods*MaleRegeneration*Treatment Outcome
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
Journal Papers > Research Organization > Cell Therapy Center
AJOU Authors
민, 병현최, 병현
Files in This Item:
Full-Text Not Available.txtDownload
RIS (EndNote)
XLS (Excel)


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.