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Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated with Acetaminophen Use during Viral Infections

Authors
Ban, GY  | Ahn, SJ | Yoo, HS  | Park, HS  | Ye, YM
Citation
Immune network, 16(4). : 256-260, 2016
Journal Title
Immune network
ISSN
1598-26292092-6685
Abstract
An association between drug treatment for viral infections and severe cutaneous adverse reactions has been noted. We investigated six patients diagnosed with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) after being prescribed acetaminophen for suspected viral illnesses. Multiplex analysis was performed to measure cytokine levels in sera before and after treatment. IL-2Ralpha levels significantly decreased during the convalescence phase. Although acetaminophen is relatively safe, the drug can trigger SJS/TEN in patients with suspected viral infections. T-cells and monocytes may be key components of the link between viral infection and acetaminophen-induced SJS/TEN.
Keywords

DOI
10.4110/in.2016.16.4.256
PMID
27574505
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Ajou Authors
박, 해심  |  반, 가영  |  예, 영민  |  유, 혜수
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