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Alleviation of osteoarthritis by calycosin-7-O-beta-D-glucopyranoside (CG) isolated from Astragali radix (AR) in rabbit osteoarthritis (OA) model.

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dc.contributor.authorChoi, SI-
dc.contributor.authorHeo, TR-
dc.contributor.authorMin, BH-
dc.contributor.authorCui, JH-
dc.contributor.authorChoi, BH-
dc.contributor.authorPark, SR-
dc.date.accessioned2011-03-07T01:29:25Z-
dc.date.available2011-03-07T01:29:25Z-
dc.date.issued2007-
dc.identifier.issn1063-4584-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1547-
dc.description.abstractOBJECTIVE: This work was undertaken to assess the protective effect of an isoflavonoid, calycosin-7-O-beta-D-glucopyranoside (CG), isolated from Astragali radix (AR) on the pathogenesis of osteoarthritis (OA)-like lesion in a rabbit model.



METHODS: Nine rabbits underwent an anterior cruciate ligament and menisectomy transection (ACLMT) of the rear knee joints to induce OA-like lesion. They were randomly divided into three groups (n=6/group): a negative control group treated with 200 microl of 0.5% (v/v) dimethyl sulfoxide (DMSO), a positive control group treated with 200 microl of 100 microM piroxicam, and a test group treated with 100 microg/500 microl of CG, where the test agents were administered by injection once a week for 4 weeks starting from the third week. Rabbits were then sacrificed to observe the progression of OA-like lesion. The synovial fluid was analyzed for the amounts of total proteins, glycosaminoglycans (GAG) and prostaglandin E(2) (PGE(2)). In addition, histopathologic analyses were performed on the OA-like articular cartilage with or without therapeutic treatments.



RESULTS: The total synovial fluid volume (P<0.05) was most strikingly reduced by the treatment with CG. Moreover, the CG treatment also significantly alleviated the OA-induced accumulation of prostaglandin (PG) (P<0.001) and total proteins (P<0.001) in the synovial fluid. The histopathologic analyses revealed that the CG treatment reduced the severity of the OA-like structural damages in the cartilage. However, the level of PGE(2), a pathologic inflammatory molecule, was not diminished by CG or piroxicam.



CONCLUSION: These results indicate that the isoflavonoid CG isolated from AR significantly alleviated the pathologic changes in the OA-like rabbit knee joints. This suggests that CG from AR could be a promising treatment for the therapy of OA.
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dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHAnterior Cruciate Ligament-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal-
dc.subject.MESHAstragalus Plant-
dc.subject.MESHCartilage, Articular-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHGlucosides-
dc.subject.MESHGlycosaminoglycans-
dc.subject.MESHIsoflavones-
dc.subject.MESHMenisci, Tibial-
dc.subject.MESHOsteoarthritis-
dc.subject.MESHPiroxicam-
dc.subject.MESHProstaglandins-
dc.subject.MESHProteins-
dc.subject.MESHRabbits-
dc.subject.MESHRandom Allocation-
dc.subject.MESHSynovial Fluid-
dc.titleAlleviation of osteoarthritis by calycosin-7-O-beta-D-glucopyranoside (CG) isolated from Astragali radix (AR) in rabbit osteoarthritis (OA) model.-
dc.typeArticle-
dc.identifier.pmid17408983-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S1063-4584(07)00081-7-
dc.contributor.affiliatedAuthor민, 병현-
dc.contributor.affiliatedAuthor최, 병현-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.joca.2007.02.015-
dc.citation.titleOsteoarthritis and cartilage-
dc.citation.volume15-
dc.citation.number9-
dc.citation.date2007-
dc.citation.startPage1086-
dc.citation.endPage1092-
dc.identifier.bibliographicCitationOsteoarthritis and cartilage, 15(9). : 1086-1092, 2007-
dc.identifier.eissn1522-9653-
dc.relation.journalidJ010634584-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
Journal Papers > Research Organization > Cell Therapy Center
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