Cited 0 times in Scipus Cited Count

Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

DC Field Value Language
dc.contributor.authorLee, HY-
dc.contributor.authorYe, YM-
dc.contributor.authorKim, SH-
dc.contributor.authorBan, GY-
dc.contributor.authorKim, SC-
dc.contributor.authorKim, JH-
dc.contributor.authorShin, YS-
dc.contributor.authorPark, HS-
dc.date.accessioned2018-07-27T00:52:08Z-
dc.date.available2018-07-27T00:52:08Z-
dc.date.issued2017-
dc.identifier.issn0105-4538-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/15579-
dc.description.abstractBACKGROUND: Clinical presentation of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease (NERD) is found to be heterogeneous. This study classified phenotypic clusters to determine NERD subtypes.
METHODS: We performed two-step cluster analysis using urticaria, chronic rhinosinusitis (CRS), and atopy, in a NERD cohort comprising 302 patients. Asthma exacerbation was defined as receiving at least one burst of intravenous steroid treatment and/or at least two bursts of oral steroid use (>/= 45 mg/3 days) per year. The possession rate of anti-asthmatic medications was estimated during the follow-up period.
RESULTS: There were four subtypes: subtype 1 (NERD with CRS/atopy and no urticaria), subtype 2 (NERD with CRS and no urticaria/atopy), subtype 3 (NERD without CRS/urticaria), and subtype 4 (NERD with urticaria). Significant differences were found between the four subtypes in the female proportion, baseline FEV1%, serum total IgE level, and sputum/peripheral eosinophil count. A higher frequency of asthma exacerbations was noted in subtype 1 compared to subtype 3. The possession rates of medium- to high-dose inhaled corticosteroids/long-acting beta2 -agonists showed significant differences among the four subtypes. Metabolomic analysis showed that the four subtypes of NERD had a higher serum leukotriene E4 (LTE4) level than those with aspirin-tolerant asthma. The patients with subtypes 1 and 3 had a higher urine LTE4 level than those with subtype 2.
CONCLUSION: We found four distinct subtypes with different clinical/biochemical findings and asthma exacerbations in a NERD cohort. These findings suggest that stratified strategies by applying subtype classification may help achieve better outcomes in the management of NERD.
-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAge of Onset-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal-
dc.subject.MESHAsthma-
dc.subject.MESHBiomarkers-
dc.subject.MESHCluster Analysis-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHInflammation Mediators-
dc.subject.MESHLeukocyte Count-
dc.subject.MESHLeukotriene E4-
dc.subject.MESHMale-
dc.subject.MESHMetabolome-
dc.subject.MESHMetabolomics-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPhenotype-
dc.subject.MESHRespiratory Function Tests-
dc.subject.MESHRespiratory Tract Diseases-
dc.titleIdentification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease-
dc.typeArticle-
dc.identifier.pmid27805264-
dc.contributor.affiliatedAuthor예, 영민-
dc.contributor.affiliatedAuthor김, 승현-
dc.contributor.affiliatedAuthor반, 가영-
dc.contributor.affiliatedAuthor신, 유섭-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/all.13075-
dc.citation.titleAllergy-
dc.citation.volume72-
dc.citation.number4-
dc.citation.date2017-
dc.citation.startPage616-
dc.citation.endPage626-
dc.identifier.bibliographicCitationAllergy, 72(4). : 616-626, 2017-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1398-9995-
dc.relation.journalidJ001054538-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Hospital > Clinical Trial Center
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse